Research Interests of the Department of Chemistry and Biochemistry

Investigative research lies at the heart of all of the experimental sciences. In chemistry, research can take many forms, from synthesizing compounds to building computational models or gathering and analyzing data using a wide variety of instruments and techniques. If you are interested in learning more about what chemists really do, joining a research group and taking on an independent research project is an excellent place to start!

 Environmental/
 Analytical

 Biochemistry  Inorganic Medicinal Nuclear  Organic  Physical  Polymer
Carmosini
Machado
Opdahl
Rolfhus
Grilley
Grunwald

Weaver
Kirsch
McGaff
Nelson
Monte Bryan Czerwinski
McGrath
Schenck
Beyer
Kirsch
Loh
Miller

Analytical Chemistry

Dr. Nadia Carmosini
My area of research is environmental chemistry of aquatic and soil systems. I'm interested in investigating the conditions and processes that influence the fate and bioavailability of environmental contaminants in soil and water. Currently, students in my lab are conducting experiments examining how two emerging antimicrobial pesticides, triclosan and triclocarban, bind to soils and dissolved organic carbon, and how this binding impacts the contaminants' bioavailability. Students interested in joining my lab should have a genuine passion for chemistry, biology and ecology. For more information, e-mail me.

Dr. Ressano DeSouza-Machado
I am seeking to develop capabilities to measure absolute molecular weights and "sizes" of macromolecules in solution. The macromolecules could be biological in nature such as proteins, or man-made as polymers. To elucidate the information, we will employ multiangle light scattering (MALS). I would also like to extend an invitation to those students who would like to tinker with instrumentation, to work with me in improving our current offerings as experiments in upper level chemistry courses. E-mail me for additional information.

Dr. Aric Opdahl
Chemistry at surfaces and interfaces; surface spectroscopy and microscopy; biosensor design; mechanical behavior of thin films; molecular assembly at interfaces. For additional information e-mail Dr. Opdahl.

Dr. Kris Rolfhus
My research interests are focused in environmental chemistry, particularly the geochemical cycling and reactivity of toxic heavy metals with significant human health effects such as mercury and arsenic. Currently, I am working with Canadian scientists to evaluate the effects of hydroelectric reservoir creation and seasonal flooding events on the microbial synthesis of methylmercury, a potent human neurotoxin. I am also studying the speciation and distribution of mercury in Lake Superior and its tributaries, as well as in the Voyageurs National Park region of northern Minnesota. These metals exist in extremely small quantities in the environment, such that contamination-free sample collection and analytical techniques are applied, as well as the use of a dedicated "clean room" facility. For additional information, e-mail me, or visit my website.

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Biochemistry

Dr. Dan Grilley
The goal of my research is to understand in mechanistic detail how the chemical properties of DNA affect its structure and thus its function inside of living cells. Specifically, my research focuses on two related problems, how do the chemical properties of DNA affect its stiffness, and how does that stiffness affect how DNA is compacted to fit inside a cell. Students interested in doing research at the interface of chemistry, biology, and physics are encouraged to contact me.

Dr. Sandy Grunwald
My research program focuses on the study of the relationship between metalloproteins. The current project is characterizing the relationship between the iron-storage protein, ferritin, and iron-containing protein, nitrogenase, in the nitrogen-fixing bacterium Azotobacter vinelandii. Since I use bacteria as a model system to study meltaaloproteins, this project is well-suited for students interested in biochemistry or microbiology. E-mail me for additional information.

Dr. Todd Weaver
Research in my laboratory is focused in two main areas. The first area of research uses the hemolysin system from Proteus mirabilis to characterize the activation of bacterial toxins during pore formation. The overall goal of this project aims to characterize the structural differences between the secreted (active) and non-secreted (inactive) forms of hemolysin A. The second area of research aims to characterize the recruitment of low-barrier hydrogen bonds during enzyme catalysis. We have numerous mutant forms of fumarase C and in the process of collecting steady-state kinetic and X-ray diffraction data on each form. E-mail me for additional information.

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Research Interests of Faculty in the Biochemistry Major Program

Inorganic Chemistry

Dr. Janet Kirsch
My research uses different computational techniques to answer fundamental questions about the bonding in solids and on surfaces. I am particularly interested in developing explanations, based on bonding theories, for the ways in which different surfaces reconstruct. E-mail me for additional information.

Dr. Rob McGaff
Research in my group is focused on finding rational synthetic routes to extended solid-state compounds in response to technological demands for such materials. We concentrate on the synthesis of transition metal compounds that are constructed by linking metal atoms with multifunctional ligands, which are chemical entities that can attach to two different metals at the same time, thus connecting them. We are particularly interested in nitriles and borate fragments as potential ligands for linking transition metals, concentrating especially on rhenium, nickel, copper, platinum, vanadium, and chromium. E-mail me for additional information.

Dr. Kendric Nelson
My research utilizes a molecular approach towards new electronic and computing components that are sought to be used in conjunction with or potentially replace traditional complementary metal-oxide-semiconductor (CMOS) materials. Traditional CMOS materials are plagued by the physical limitation of size reduction that has been driving advancements over the past 50 years and the "bottom-up" approach is one potential solution to this "top-down" one. The molecule-based approach allows a synthetic chemist to pick-and-choose molecular precursors and potentially "dial-up" and "tune-in" desired chemical/physical properties. Our focus is on the design, synthesis, and characterization of new molecule-based materials (MBMs) that have the potential to be used to develop next generation computers and electronics. E-mail me for additional information.

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Medicinal Chemistry

Dr. Aaron Monte
Researchers in my labs are involved in the application of organic chemistry techniques to the discovery, synthesis, and development of new drug molecules.  In one area, we have been trying to identify new antibiotics present in wild fungi and green plants.  We are now attempting to synthesize several analogs of one natural product we discovered in the leaves of the “sweet fern” plant, which grows near Lake Superior and has been used in traditional medicine by Wisconsin Native Americans.  In another area, we are attempting to better understand the mechanism of action of psychedelic drugs and how they influence the function of certain serotonin receptors and neurons.  Here, we prepare rigid analogs of classic hallucinogenic phenethylamines using standard organic synthetic methods. E-mail me for additional information.

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Nuclear Chemistry

Dr. Jeff C. Bryan
My research interests involve finding new and exciting ways to bring nuclear chemistry to the the masses. Current projects include a new edition of my textbook, and writing a nuclear chemistry chapter for a general chemistry textbook. Future work could involve the making of nuclear chemistry podcasts and development of a web-based interactive 3-D chart of the the nuclides for the web. I'm also working with Dr. Lesher in the Physics Department to analyze radioactive nuclides in environmental samples and with Dr. Kirsch (Chemistry) on the design and synthesis of new inorganic compounds that may also serve as radiopharmaceutical. For additional information, e-mail me or drop by my office in 441 Cowley Hall.

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Organic Chemistry

Dr. Curt Czerwinski
My research interests are in the area of organometallic chemistry, specifically as related to the synthesis of molecules that mimic industrial catalysts and the discovery of new organometallic reactions. Organometallic chemistry targets the interface between organic chemistry, the study of carbon-based molecules, and inorganic chemistry, the study of metals like chromium, tungsten, and iron. Combining these two areas involves synthesizing new molecules that have metal-carbon bonds and exploring reactions otherwise unavailable in traditional organic or inorganic chemistry. My research group synthesizes air-sensitive organometallic molecules using equipment that allows for manipulation of chemicals without exposing them to air, and studies the structure and rearrangement mechanisms of these molecules using infrared and nuclear magnetic resonance spectroscopy. E-mail me for additional information.

Dr. Nicholas McGrath
The goal of my research is to develop new chemical reactions that can be used as tools to study biological systems. Specifically, my research involves exploiting the chemoselective reactivity of azides and diazo compounds for novel ligation reactions, which allows us to probe and manipulate protein structure and labeling. The research will challenge students to develop a well-rounded perspective on chemical reactivity, protein structure and function, and biological processes, which will be valuable as they begin their scientific careers. Please e-mail me if you would like to learn more about this research.

Dr. Heather Schenck
My research interests lie in structural organic chemistry. I am currently working with three undergraduate researchers to explore the solution state structure of hydroxamic acids. These unusual acids bind iron very strongly. Hydroxamic acids appear most commonly in mid-sized organic molecules called siderophores, which are used by bacteria, fungi, and algae to obtain iron needed for growth. Native siderophores show extremely high association constants for iron, which aid microbes in obtaining scarce ferric iron. However, we have discovered that the preferred structure of at least one hydroxamic acid in water is actually the wrong shape: not the form that can bind iron (Magn. Reson. Chem. 2013, 51, 72-75). We are exploring the structural preferences of hydroxamic acids, as well as the energy barriers between favored forms, using NMR spectroscopy. Please contact me by e-mail to learn more about this research.

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Physical Chemistry

Dr. Keith Beyer
My research interests involve the formation of atmospheric clouds as governed by phase diagram thermodynamics. The formation of cirrus clouds in the upper troposphere and lower stratosphere are my current interest. Cloud formation at this level impacts global climate and can have an impact on atmospheric chemical reactions through chemistry that occurs at the surfaces of these particles. My current NSF grant supports research on the impact of inorganic and organic chemicals on the freezing of particles that lead to cirrus cloud formation. E-mail me for additional information.

Dr. Janet Kirsch
My research uses different computational techniques to answer fundamental questions about the bonding in solids and on surfaces. I am particularly interested in developing explanations, based on bonding theories, for the ways in which different surfaces reconstruct. E-mail me for additional information.

Dr. Adrienne Loh
My research program is centered on peptide and protein structure and dynamics. The way that a given protein functions is governed by its shape (its structure) and the way that it moves (its dynamics). We are using short helical peptides as models of large proteins. Students in my group have the opportunity to synthesize the molecules of interest, then characterize the structure and flexibility of their peptides using nuclear magnetic resonance (NMR) spectroscopy. For further information, e-mail me, stop by my office, 4016 Cowley Hall.

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Polymer Chemistry

Dr. Paul Miller
The focus of my research is in the area of polymer chemistry. More specifically, my interest is in the physical and chemical behavior of polymer colloids (latexes) as well as their potential applications. By altering the chemical composition of the latex, we can "tune" the latex to be more or less compatible with certain substrates. Also, we can build catalytic sites into the latex particles, which can increase their activity and lead to new applications. Here at UW-La Crosse, my research is centered on using polymer latexes for drug delivery as well as for the catalytic neutralization of organic contaminants (chlorinated hydrocarbons, pesticides, etc.) in ground water. E-mail me for additional information.

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“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.” – Albert Einstein