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Investigative research lies at the heart of all
of the experimental sciences. In chemistry, research can take many
forms, from synthesizing compounds to building computational models
or gathering and analyzing data using a wide variety of instruments
and techniques. If you are interested in learning more about what
chemists really do, joining a research group and taking on an independent
research project is an excellent place to start!
Dr.
Scott Cooper, Molecular Biology Dr.
Sandra Grunwald, Biochemistry Dr. Adrienne
Loh, Biophysical Chemistry Dr.
Jennifer A. Miskowski, Cell Biology Dr.
Todd Weaver, Biochemistry
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University
of Wisconsin-La Crosse 1725 State Street La Crosse, Wisconsin 54601 (608) 785-8000
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My
research focuses on using molecular techniques to understand the
mechanism by which anticoagulants inhibit blood clotting. To do
this we mutate the gene for human antithrombin and then express
these proteins in insect cells. We then purify the proteins and
assay them to see how the changes we have introduced change the
activity of the inhibitor. Eventually this could lead to the development
of therapeutic drugs. For more information contact 
My research program focuses on the study of the relationship
between metalloproteins. The current project is characterizing
the relationship between the iron-storage protein, ferritin,
and iron-containing protein, nitrogenase, in the nitrogen-fixing
bacterium Azotobacter vinelandii. Since I use bacteria as a
model system to study meltaaloproteins, this project is well-suited
for students interested in biochemistry or microbiology. For
more information contact: 
My
research program is centered on peptide and protein structure and
dynamics. The way that a given protein functions is governed by
its shape (its structure) and the way that it moves (its dynamics).
We are using short helical peptides as models of large proteins.
Students in my group have the opportunity to synthesize the molecules
of interest, then characterize the structure and flexibility of
their peptides using nuclear magnetic resonance (NMR) spectroscopy.
Research
in my laboratory is focused in two main areas. The first area of
research uses the hemolysin system from Proteus mirabilis to characterize
the activation of bacterial toxins during pore formation. The overall
goal of this project aims to characterize the structural differences
between the secreted (active) and non-secreted (inactive) forms
of hemolysin A. The second area of research aims to characterize
the recruitment of low-barrier hydrogen bonds during enzyme catalysis.
We have numerous mutant forms of fumarase C and in the process of
collecting steady-state kinetic and X-ray diffraction data on each
form. For more information contact: