Faculty
and Staff
University of
Wisconsin – La
Crosse
Michael A. Hoffman, Ph.D., Department of Microbiology
Dr. Hoffman is a Professor in the
Department of Microbiology and Director of the Clinical Microbiology
Master’s
Program. Much of his research focuses on the gene expression
and assembly of human parainfluenza virus type 3, a respiratory
tract
pathogen. Additional research interests include the identification and characterization of fish viruses.
Recent Publications:
Hoffman, M.A, L.M Thorson, J.E. Vickman, J.S. Anderson, N.A. May and M.N. Schweitzer. 2006. Roles of human parainfluenza virus type 3 bases 13 to 78 in replication and transcription: Identification of an additional replication promoter element and evidence for internal transcription initiation. J. of Virology. 80:5388-96.
Malur A.G., M.A.Hoffman and A.K. Banerjee. The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription. 2004. Virus Res. 99(2):199-204.
Marc Rott, Ph.D., Department of Microbiology
Dr. Rott is a Associate Professor in the Department
of Microbiology. His research focuses on the identification and development
of novel antimicrobial compounds from plants and fungi.
Recent Publications:
Kabir MS, Engelbrecht K, Polanowski R, Krueger SM, Ignasiak R, Rott M, Schwan WR, Stemper ME, Reed KD, Sherman D, Cook JM, Monte A., New classes of Gram-positive selective antibacterials: Inhibitors of MRSA and surrogates of the causative agents of anthrax and tuberculosis.Bioorg Med Chem Lett. 2008 Sep 26. [Epub ahead of print]
Schwan, W.R., Monte, A.P., Rott, M.A., Defoe, L., Anti-infective agents and methods of use. United States Patent, Applied for on Oct 18, 2005.
William Schwan, Ph.D., Department of Microbiology
Dr. Schwan is an Associate Professor in the Department
of Microbiology. His research focuses on the regulation of type 1
pilus expression in uropathogenic Escherichia coli, the role of proline
transport in Staphylococcus aureus pathogenesis and molecular epidemiology
of community-acquired methicillin resistant Staphylococcus aureus.
Recent Publications:
Schwan WR.Flagella allow uropathogenic Escherichia coli ascension into murine kidneys.Int J Med Microbiol. 2008 Jul; 298 (5-6): 441-7 .
Schwan WR, Shibata S, Aizawa S, Wolfe AJ. The Two-Component Response Regulator RcsB Regulates Type 1 Piliation in Escherichia coli.J Bacteriol. 2007 Oct;189(19):7159-63.
Schwan, W.R., L. Lehmann and J. McCormick. 2006. Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during infection of murine and human tissues. Infect. Immun. 74:399-409.
Bernadette Taylor, Ph.D., Department of Microbiology
Dr. Taylor-Winfrey is an Associate Professor in the Department of Microbiology. Her research focus is the investigation of the human antibody and T cell response to low-dose intradermal influenza vaccination. She is also engaged in a collaborative project that may uncover new immunosuppressive, or cancer inhibiting drugs in compounds
present in fungi found in Wisconsin.
Recent Publication:
Taylor B.C., R.M. Brotheridge, D.A. Jessup, and
J.L. Stott. 2002. Measurement of serum immunoglobulin concentration
in killer whales and sea otters by radial immunodiffusion. Vet. Immunol. Immunopathol. 89:187-95.
Michael Winfrey, Ph.D., Department of Microbiology
Dr. Winfrey is a Professor in the Department of Microbiology. His research interests include: i) identification of novel antimicrobial agents from black walnut hulls and other plant products, ii) microbial cycling of mercury in the environment and iii) characterization of probiotic organisms from kefir grains. Dr. Winfrey was Chair of the Department of Microbiology for the past 10 years and wasn't able to do much research during that time. But he has a lot of publicaitons from prior to that!
Nick Downey, Ph.D., Department of Biology
Dr. Downey is an Assistant Professor in the Department of Biology. His research focuses on the mitochondrial DNA (mtDNA) of the parasite Trypanosoma brucei. He uses bioinformatic approaches to identify and then analyze proteins that may be involved in mitochondrial segregation and mtDNA replication. The hope is that this research will identify new approaches to develop effective anti-trypanosomal drugs.
Recent Publication:
Downey, N., Hines, J. C., Sinha, K. M. and D. S. Ray (2005) “Mitochondrial DNA Ligases of Trypanosoma brucei” Eukaryotic Cell vol 4 (4) pp765-774
Tom Volk, Ph.D., Department of Biology
Dr. Volk is a Professor in the Department of Biology.
His research focuses on just about anything that has to do with fungi,
including medical mycology. Some recent student projects have included
work on Blasotmyces, Penicilium morneffei, and Candida albicans.
See TomVolkfungi.net for more information.
Recent Publication:
Burgess JW, Schwan WR, Volk TJ. 2006. PCR-based detection of DNA from the human pathogen Blastomyces dermatitidis from natural soil samples. Med Mycol. Dec;44(8):741-8.
Todd Weaver, Ph.D., Department of Chemistry
Dr. Weaver is a Professor in the Department of Chemistry. His research lab is focused in two main areas. The first area of research aims to describe the activation of bacterial toxins for membrane insertion. The second area of research involves mechanistic studies of enzymes.
Recent Publications:
Bailey L, Agger S, Peterson L, Thompson J, Weaver T. 2005. Crystallization of truncated hemolysin A from Proteus mirabilis. Acta Crystallograph Sect F Struct Biol Cryst Commun. 2005 Apr 1;61(Pt 4):448-50.
Weaver T. 2005. Structure of free fumarase C from Escherichia coli. Acta Crystallogr D Biol Crystallogr. Oct;61(Pt 10):1395-401.
Gundersen Lutheran Medical Center
The Gundersen Lutheran Research Page
William A. Agger, M.D., Section of Infectious Diseases
Dr. Agger is the Director of Research and Chairman of the Section
of Infectious Diseases at Gundersen Lutheran. His research interests
include antimicrobial resistance and tick-borne infectious diseases.
Recent publications:
Friedlander, S.L., K.Y. Dooms, C.M. Seroogy, C.Y. Voss, W.A. Agger, K. Zhang, J. Bleesing, and A.H. Filipovich. 2008. Adolescent presentation of x-linked lymphoproliferative disease. Ann Allergy Asthma Immunol. 100:398-400.
Feder, H.M. Jr., B.J. Johnson, S. O’Connell, E.D. Shapiro, A.C Steere, G.P. Wormser, W.A. Agger, et.al. 2007. A critical appraisal of “chronic Lyme disease”. N. Engl. J. Med. 357:1422-1430.
Agger, W.A. and R.M. Naik. 2006. How should we approach adolescent and adult pertussis? WMJ. 2006 105:47-51.
Steven M. Callister, Ph.D., Section of Infectious Diseases and Microbiology
Research
Dr. Callister is a senior research scientist
in the Microbiology Research Laboratory.
Dr. Callister’s research focuses on pathogenesis and immune
responses during infections with spirochetal bacteria.
Recent publications:
Nardelli, D.T., S.M. Callister, and R.F. Schell. 2008. Lyme arthritis: current concepts and a change in paradigm. Clin. Vacc. Immunol. 15:21-34.
Nardelli, D.T., K.H. Kevin Luk, N.J. Kotloski, T.F. Warner, J.R. Torrealba, S.M. Callister, and R.F. Schell. 2008. Role of IL-17, transforming growth factor-beta, and IL-6 in the development of arthritis and production of anti-outer surface protein A borreliacidal antibodies in Borrelia-vaccinated and -challenged mice. FEMS Immunol Med Microbiol. 53:265-74.
Kotloski, N.J., D.T. Nardelli, S.H. Peterson, J.R. Torrealba, T.F. Warner, S.M. Callister, and R.F. Schell. 2008. Interleukin (IL)-23 is Required for the Development of Arthritis in Borrelia-Vaccinated and -Challenged Mice. Clin Vacc. Immunol. Jun 25. [Epub ahead of print]
Dean A. Jobe, M.S., RM(AAM), Microbiology Research Laboratory
Dean Jobe is the supervisor of the Microbiology Research Laboratory.
His research focuses on antibody responses during bacterial infections
and development of diagnostic tests.
Recent publications:
Jobe, D.A., S.D. Lovrich, K.E. Asp, M.A. Mathiason, S.E. Albrecht, R.F. Schell, and S.M. Callister. 2008. Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC. Clin. Vacc. Immunol. 15:981-985.
Go, R.S., D.A. Jobe, K.E. Asp, S.M. Callister, M.A. Mathiason, L.A. Meyer, W.A. Bottner, C.E. Cole, J.P. Farnen, and K.A. Frisby. 2008. Circulating endothelial cells in patients with chronic lymphocytic leukemia. Ann. Hematol. 87:369-373.
Jobe, D.A., J.A. Nelson, M. Adam, and S. Martin. 2007. Increasing risk of Lyme disease in urban areas near Chicago. Emerg. Infect. Dis. 13:1799-1800.
Steven D. Lovrich, Ph.D., Microbiology Research Laboratory
Dr. Lovrich is a molecular biologist in the Microbiology Research
Laboratory. His research focuses on identification, purification,
and characterization of bacterial protein vaccine candidates.
Recent publications:
Lovrich, S.D., R.L. LaFleur, D.A. Jobe, J. Johnson, R.F. Schell, and S.M. Callister. 2007. The canine borreliacidal OspC antibody response differs significantly from human Lyme disease. Clin. Vacc. Immunol. 14:635-637.
Jobe, D.A., S.D. Lovrich, K.E. Asp, M.A. Mathiason, S.E. Albrecht, R.F. Schell, and S.M. Callister. 2008. Significantly improved accuracy of diagnosis of early Lyme disease by peptide enzyme-linked immunosorbent assay based on the borreliacidal antibody epitope of Borrelia burgdorferi OspC. Clin. Vacc. Immunol. 15:981-985.
Jeffrey S. Sartin, M.D., Section of Infectious Diseases
Dr. Sartin is an internal medicine physician in the Section of Infectious
Diseases. His research interests include studies evaluating the historical
perspective of infectious diseases.
Recent publications:
Sartin, J.S., T.E. Rydmark, J.E. Robinson, and M.A. Michaels. 2007. Implementing CAP guidelines: impediments and opportunities. Wis. Med. J. 106:205-10.
Sartin, J.S. and K.R. Oettel. 2006. A morphealike skin condition caused by Borrelia burgdorferi in an immunocompromised patient. Mayo Clin Proc. 81:1259-60.
Schlicht M.J., Lovrich S.D., Sartin J.S., Karpinsky P., Callister S.M., Agger W.A. High prevalence of genital mycoplasmas among sexually active young adults with urethritis or cervicitis symptoms in La Crosse, Wisconsin. J. Clin. Microbiol. 2004 Oct;42(10):4636-40.
Carl Simon Shelly, Ph.D., Director, Hematology/Oncology Research
The pathogenesis of a host of diseases and pathologic states is driven by abnormal cellular adhesion. These conditions include cancer, atherosclerosis, diabetes, leukemia, and immunodeficiency diseases such as AIDS, and the ischemic reperfusion injury that occurs in frost bite, organ transplant, limb reattachment and after a heart attack or stroke. The research undertaken by Dr. Shelley's program is aimed at determining the basic molecular mechanisms that control pathologic cell adhesion such that new therapeutic targets can be developed.
Sylvie Galie`gue-Zouitina, Laure Delestre´, Caroline Dupont, Xavier Troussard, and Carl Simon Shelley. 2008. Underexpression of RhoH in Hairy Cell Leukemia. Cancer Res. 68 (12), 4531-40.
Kong, T., Eltzschig, H. K., Karhausen, J., Colgan, S. P. and Shelley, C. S. (2004). Leukocyte adhesion during hypoxia is mediated by HIF-1 dependent induction of β2 integrin gene expression. Proc. Natl. Acad. Sci. USA, 101, 10440-10445.
Marshfield Clinic / St. Joseph’s
Hospital
All of the Marshfield faculty are part of the Marshfield Clinic Research Foundation
Mark Borchardt, Ph.D, National Farm Medicine Center
Dr. Borchardt's research focuses on assesing the human health threat of microorganisms in the environment, with an emphasis on viruses found in drinking water.
Recent publications:
Borchardt MA, Bradbury KR, Gotkowitz MB, Cherry JA, Parker BL. Human enteric viruses in groundwater from a confined bedrock aquifer. Environ Sci Technol 2007;41:6606-6612.
Hoffman RM, Wolk DM, Spencer SK, Borchardt MA. Development of a method for the detection of waterborne microsporidia. J Microbial Methods 2007;70:312-318.
Borchardt M.A., Haas N.L., Hunt R.J. Vulnerability of drinking-water wells in La Crosse, Wisconsin, to enteric-virus contamination from surface water contributions. Appl. Environ. Microbiol. Oct;70(10):5937-46.
Jennifer Meece, Ph.D., Clinical Research
Dr. Meece is a vector biologist in the Clinical Research Center
at Marshfield Clinic Research Foundation. Her research interests
include the genetics of infectious disease transmission in mosquitoes
and the ecology of infectious diseases.
Recent publications:
Meece JK, Reynolds CE, Stockwell PJ, Jenson TA, Christensen JE, Reed KD. 2005 Identification of mosquito bloodmeal source by terminal restriction fragment length polymorphism profile analysis of the cytochrome B gene. J Med Entomol. Jul;42(4):657-67.
Meece, J.K., J.S. Henkel, L. Glaser, and K.D. Reed. 2003. Mosquito
surveillance for West Nile virus in southeastern Wisconsin - 2002.
Clin. Med. Res. 1:37-42.
Sanjay Shukla, Ph.D., Clinical Research
Dr. Shukla is a research scientist at the Marshfield Clinic Research
Foundation. His research interests include the genetics and epidemiology
of methicillin resistant Staphylococcus aureus, determination of
infectious etiology of chronic diseases, and discovery, characterization
and phylogenetic analysis of novel pathogens.
Recent publications:
Shukla SK. 2005. Community-associated methicillin-resistant Staphylococcus aureus and its emerging virulence. Clin Med Res. May;3(2):57-60.
Christensen JE, Reynolds CE, Shukla SK, Reed KD. 2004. Rapid molecular diagnosis of lactobacillus bacteremia by terminal restriction fragment length polymorphism analysis of the 16S rRNA gene.Clin Med Res. Feb;2(1):37-45.
Mary Stemper, M.S., Clinical Microbiology and Clinical Research
Mary is a molecular epidemiologist at Marshfield Clinic. Her research interests include the epidemiology of nosocomial pathogens, particularly investigations of methicillin-resistant Staphylococcus aureus and the detection of clinical pathogens based on the analysis of the 16S rRNA gene.
Recent Publications:
Brady JM, Stemper ME, Weigel A, Chyou P, Reed KD, Shukla SK. Sporadic 'Transitional-like' Community-Associated Methicillin-Resistant Staphylococcus aureus Strains from the United States. J Clin Microbiol 2007;45:2654-2661.
Morgan W, Caldwell MD, Brady JM, Stemper ME, Reed KD, Shukla SK. Necrotizing fasciitis due to a methicillin-sensitive Staphylococcus aureus harboring an enterotoxin gene cluster. J Clin Microbiol 2007;45:668-671.
Wisconsin State Laboratory of Hygiene
Pete Shult, Ph.D., Communicable Disease Division
Dr. Schult is Director of the Communicable Diseases Division and
Emergency Laboratory Response. He also serves as statewide coordinator
for laboratory response to bioterrorism and pandemic influenza planning.
Recent publications:
Gern JE, Brooks GD, Meyer P, Chang A, Shen K, Evans MD, Tisler C, Dasilva D, Roberg KA, Mikus LD, Rosenthal LA, Kirk CJ, Shult PA, Bhattacharya A, Li Z, Gangnon R, Lemanske RF Jr. 2006. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol. Jan;117(1):72-8.
Shult PA, Kirk C. 2003. Laboratory-based surveillance for influenza: role of the Wisconsin State Laboratory of Hygiene. WMJ. 102(6):26-30.
Dave Warshauer, Ph.D., Communicable Disease Division
Dr. Warshauer is Chief Bacteriologist for the Communicable Diseases
Division and coordinates molecular and other diagnostic test development
for agents of public health importance including bioterrorism.
Recent publications:
Feltus DC, Giddings CW, Schneck BL, Monson T, Warshauer D, McEvoy JM. 2006. Evidence supporting zoonotic transmission of Cryptosporidium in Wisconsin. J Clin Microbiol. 2006 Sep 27; [Epub ahead of print]
Okwumabua O, O'Connor M, Shull E, Strelow K, Hamacher M, Kurzynski T, Warshauer D. 2005. Characterization of Listeria monocytogenes isolates from food animal clinical cases: PFGE pattern similarity to strains from human listeriosis cases. FEMS Microbiol Lett. Aug 15;249(2):275-81.
Bob Garrison, D.V.M., M.S., Communicable Disease Division
Dr. Garrison directs Division Operations,
the laboratory’s
zoonotic diseases program. In addition, he assists the Director
of the Communicable Disease Division in emergency laboratory
response
and planning.
Other affiliated faculty
Sylvia A. Firary, M.D., Infectious Diseases, Gundersen Lutheran
Medical Center
Carol Kirk, B.S., Respiratory Diseases, Wisconsin State Laboratory
of Hygiene
Kathy Leske, B.S., MT(ASCP), Microbiology, Gundersen Lutheran Medical
Center
Jennifer A. Marks, B.S., Microbiology Research, Gundersen Lutheran
Medical Center
Jim McCormick, B.S., MT(ASCP), Microbiology, Gundersen Lutheran
Medical Center
Tim Monson, M.S., Food and Water-Borne Diseases, Wisconsin State
Lab of Hygiene
Kathy Mruz, B.A., MT(ASCP), Virology, Gundersen Lutheran Medical
Center
Thomas Novicki, Ph.D., Microbiology, Marshfield Clinic
Eric Reisdorf B.S., Molecular Diagnostics and Virology
Phil Wand, M.S., Mycobacteriology, Wisconsin State Laboratory of
Hygiene
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