MIC 500 Cr. 1
Orientation to Clinical Microbiology
This course will explore
opportunities within clinical microbiology including public health,
diagnostic testing, pharmaceutical sales, and basic research and
development. Discussion will focus on academic and professional
requirements for each career track. Information retrieval and oral
and written communication skills relevant to clinical microbiology
will also be covered. Offered by resident faculty and visiting
lecturers. Prerequisites: MIC 230 or equivalent; admission to the
Clinical Microbiology program or consent of the instructor. Offered
Sem. I. Pass/Fail grading.
MIC 406/506 Cr. 4
An introduction to how the
immune system protects against infectious disease and how it can
contribute to disease. A discussion of fundamental characteristics of
innate and acquired immunity is followed by study of antigens,
antibodies, the major histocompatibility complex, T and B lymphocyte
recognition of antigen and response, cytokines and immune regulation,
hypersensitivity reactions including allergies, and the immune system
in AIDS. Lect. 2, Lab. 4. Prerequisites: MIC 230; BIO 303 or 313 and
CHM 300 or 303
MIC 407/507 Cr. 4
The study of pathogenic
bacteria and their relationships to disease; principles of infection
and pathogenesis, and unique properties of pathogens. Laboratory
emphasis is on techniques for isolation and identification of
pathogenic bacteria. Not applicable to biology major; may be applied
to the microbiology, medical laboratory science major and/or degree
as well as an elective for the biology biomedical concentration.
Lect. 2, Lab 4. Prerequisites: MIC 230 and 406/506 (may be taken
MIC 416/516 Cr. 5
An in-depth study of the
bacterial and bacteriophage genome with emphasis on the central
dogma. Specific topics include DNA replication, transcription and
translation, DNA mutation and repair, regulation of gene expression,
mechanisms of genetic exchange, plasmid structure and function,
transposition, gene mapping and recombinant DNA technology.
Laboratory emphasis is on the techniques used in bacterial
mutagenesis, genetic exchange, gene mapping, and gene cloning. Lect.
2, Lab.6. Prerequisites: MIC 406, four semesters of college
chemistry including organic, and admitted to microbiology major.
Offered Sem. I.
MIC 420/520 Cr. 3
An introduction to viruses and
their interactions with host organisms. Special emphasis is placed on
the structure and replication cycles of virus families with medical
importance. Prerequisites: MIC 230 and MIC 426 or BIO 306 or BIO
435/535 and three semesters of college chemistry to include organic
chemistry. Offered Sem. II.
MIC 421/521 Cr. 2
A laboratory course designed
to introduce fundamental techniques used to study viruses in
medicine, biotechnology and research. Emphasis is on procedures used
to safely handle viruses, grow them in tissue culture, and the
molecular biological, biochemical and immunological techniques used
to detect and analyze viruses. Lab. 4. Prerequisites: MIC 230 and
MIC 416 or BIO 306 or BIO 435/535 and three semesters of college
chemistry to include organic chemistry. Offered Sem. II.
MIC 425/525 Cr. 5
An in-depth study of bacterial
structure and function, catabolic and anabolic pathways, regulation,
and macromolecular synthesis. Laboratory emphasis is on current
techniques used to examine bacterial structure and metabolism such as
macromolecular separations and quantification, use of radioisotopic
tracers and quantification of enzyme activity. Lect. 2, Lab. 6.
Prerequisites: MIC 406, MTH 150 or higher, CHM 301 and CHM 300 (or
303), and admitted to microbiology major. Offered Sem. II.
MIC 426/526 Cr. 4
A study of environmental
factors affecting the growth, activity, and destruction of
micro-organisms in food; principles of food spoilage; preservation of
foods, including basic methods and their application to foods;
food-borne intoxications and infections; indicator organisms;
sanitation and microbiological standards in foods. Laboratory
instruction includes quality control methods, sampling methods,
techniques to identify important microorganisms in foods, and data
interpretation and analysis. Lect. 2, Lab. 4. Prerequisites:
MIC 230; BIO 412/512 strongly recommended. Offered Sem. I.
MIC 427/527 Cr. 3
Industrial and Fermentation Microbiology
A study of microbiology and
biochemistry of food fermentations; bioconversions; production of
antibiotics, vitamins, amino acids and organic acids. Starter culture
systems will be examined. Prerequisite: MIC 230; MIC 426/526 strongly
recommended. Offered Sem. II.
MIC 428/528 Cr.2
Fermentation Microbiology Laboratory
Principles of fermentation
science and biotechnology with emphasis on industrial and food
fermentation processes. Laboratory emphasis is on the use of various
fermentation systems that generate useful products including
fermented food and beverages, pharmaceuticals, fine chemicals and
other gene products. Lab. 4. Prerequisites: MIC 426 or 427 and three
semesters of college chemistry. Offered Sem. II.
MIC 434/534 Cr. 3
Aquatic Microbial Ecology
An ecological study of
bacteria, cyanobacteria and algae of aquatic ecosystems. Topics
include microbial strategies for survival under various environmental
conditions, the role of micro-organisms in biogeochemical cycling of
elements, interactions of microorganisms with other aquatic biota,
the role of micro-organisms in pollution problems, and applications
of microbial ecology to biotechnology. Laboratory emphasis is on
experimental design and sampling techniques, quantification of
microbial biomass, and measurement of microbial activities in aquatic
habitats. One weekend field trip required. Lect. 2, Lab. 3.
Prerequisites: MIC 230 and three semesters of college chemistry; BIO
341 strongly recommended. Offered Sem. I, alternate years.
MIC 440/540 Cr. 2
In this course, students will
use computers to study and compare the sequence of nucleotides in DNA
or RNA, or the amino acids in a protein. Computers are also used to
examine the three dimensional structure of proteins. Being able to
manipulate and study this information is the basis for the current
revolution in Biotechnology. Topics include evolution, taxonomy,
genomics and understanding disease. This course provides students an
opportunity to explore the relationships between biology,
microbiology, chemistry and computer science. Lect. 1, Lab. 2.
Prerequisites: BIO 306 or MIC 230 (BIO 435 or MIC 416 recommended).
Cross-listed with BIO 440/540; may only earn credit in MIC or BIO.
Offered Sem. II or J-term
MIC 454/554 Cr. 2
Mechanisms of Microbial Pathogenicity
The study of mechanisms of
microbial pathogenicity including both overt microbial factors and
complex interactions with the host that produce symptoms of disease.
The cellular, biochemical, molecular, and genetic bases for modern
understanding of microbial disease will be
included. Prerequisite: MIC 406/506 or equivalent and MIC 407/507 or
equivalent. Offered Sem. II.
MIC 460/560 Cr. 1-3
Symposium in Microbiology
Varying topics in microbiology
with a specific title assigned to each. Offered by resident faculty
or visiting lecturers. Prerequisite: MIC 230. Repeatable for
MIC/BIO 714 Cr. 3
The application of
molecular-genetic analysis to problems in modern biology. The course
will cover the fundamentals of genetic analysis in both prokaryotic
and eucaryotic systems. Assigned readings from current literature
will be discussed and evaluated. A variety of topic areas will be
considered, including ecology, biotechnology, bioremediation, food
science, medicine, and basic research. Prerequisites: a previous
course in genetics, microbial genetics or molecular biology.
(Cross-listed with BIO.) Offered Sem. II, alternate years.
MIC/BIO 721 Cr. 1-2
Directed readings or
presentation of material not available in formal departmental
courses. (Cross-listed with BIO.) Repeatable for credit --
maximum 4 between BIO and MIC.
MIC 730 Cr. 2
Biodegradation and Bioremediation of
Microbes are able to
breakdown, or biodegrade, a wide variety of compounds including some
considered hazardous to human health and/or the environment. The use
of microbes as biological agents to reclaim polluted soils and waters
is called bioremediation. This course will explore some of the
better-studied mechanisms used by microbes to degrade and detoxify
contaminants. Practical aspects for the use of microbes in
bioremediation and some specific examples will also be covered. In
addition, the students will present and discuss a series of special
topics such as nuclear waste bioremediation or current clean-up
efforts in the news. Prerequisites: one semester organic chemistry,
MIC 230 or equivalent microbiology course. Offered Sem. I, alternate
MIC/BIO 751 Cr. 1
In this course students will
research and present a formal seminar on a selected topic in biology
or microbiology. Students are also expected to actively participate
in discussion of other seminar presentations. (Cross-listed with
BIO.) Repeatable for credit -- maximum 2.
MIC 752 Cr. 2
Clinical Laboratory Management
Advanced principles, theories,
and techniques of supervisory skills, scheduling, ordering and
personnel management of all aspects of the clinical microbiology
laboratory. In addition, compliance with federal (i.e., OSHA, CLIA
1988, CAP, etc.) and state regulations, including proficiency
testing, will be discussed. Prerequisite: acceptance into M.S.
Biology: Clinical Microbiology Program. Offered Sem. I.
MIC 753 Cr. 2
Epidemiology of Infectious Disease
This course examines the
causes, distribution, control, and prevention of infectious disease
in human populations. Basic epidemiological concepts, including study
design, analysis and modeling of infectious disease data,
establishing causal relationships, detecting confounding factors, and
assessing risk will be presented. Emphasis will be placed on issues
of special interest to the clinical epidemiologist including
laboratory diagnosis used in outbreak investigations by
microbiological, serological and molecular techniques. In addition,
methods to evaluate the accuracy and usefulness of diagnostic tests
will be examined. Prerequisites: MIC 407/507 or equivalent course.
MTH 205 or MTH 250 or HED 755. Offered Sem. II.
MIC 755 Cr. 2
An in-depth study of advanced
topics in immunology, primarily focusing on the genetics, mechanisms,
and regulation of the immune system. Aspects of the immune response
in a variety of disease conditions (infectious and non-infectious)
will be discussed. Prerequisite: MIC 406/506 or equivalent. Offered Sem. I.
MIC 761 Cr. 2
Research and Seminar in Microbiology
In-depth literature review of
a current research topic in microbiology. As part of the requirements
for this course and for the degree each student must complete an
acceptable seminar paper under the direction of an assigned faculty
member. Not applicable to students pursuing a Plan A thesis.
MIC 770 Cr. 5
Clinical Microbiology Practicum I
Students spend 9 full-time
weeks (30 hrs/wk) in the clinical laboratories at Gundersen Lutheran
Medical Center where they receive training and hands-on experience in
clinical microbiology, immunology, parasitology, mycology, and
virology. In addition, students will actively participate with
physicians, residents, and medical students in weekly infectious
disease rounds and journal club. Prerequisites: acceptance into M.S.
Biology: Clinical Microbiology Program.
MIC 780 Cr. 4
Clinical Microbiology Practicum II
Students spend 6 full-time
weeks (30 hrs/wk) in the clinical laboratories at Marshfield
Laboratories/St. Joseph's Hospital/Marshfield Clinic. Training will
include hands-on experience with state-of-the art molecular biology
techniques. Specific exercises involving molecular epidemiology and
infection control will be emphasized. Students will also participate
in infectious disease rounds and journal club. Prerequisites:
acceptance into M.S. Biology: Clinical Microbiology Program.
MIC 790 Cr. 2
Clinical Microbiology Practicum III
Students will spend 2
full-time weeks (30 hrs/wk) at the Wisconsin State Laboratory of
Hygiene for public health training in mycobacteriology, sexually-transmitted diseases,
food-and water-borne diseases, and community respiratory illness
surveillance. Emphasis will be on prevention and control programs and
outbreak responses currently in place at the Wisconsin Department of
Health. Prerequisites: MIC 770 and MIC 780.
MIC 799 Cr. 1-15
Research: Master's Thesis
Independent research in
microbiology on a problem selected for a thesis under the direction
of an assigned faculty major adviser. For students following Plan A.
Lab. 2-18. Repeatable for credit -- maximum 15; maximum six
applicable to degree.