Scott T. Cooper, Professor of Biology
Phone: (608)-785-6983 E-Mail: email@example.com
B.S. Biochemistry - Michigan State University, 1986
Ph.D. Biochemistry - University of Wisconsin-Madison, 1992
Courses Currently Taught:
BIO 103 Introductory Biology
BIO 105 General Biology
BIO 433 Radiation Biology
BIO 435 Molecular Biology
BIO 436 Molecular Biology Lab
BIO 440 Bioinformatics
BIO 443 Molecular Mechanisms of Disease and Drug Action
Advisor for UWL Triathlon Club
Introductory Biology is a non-majors course that uses issues-based modules to teach the basic elements of biology. Units include Ecology, Cells, Genetics, Evolution and Populations. The lab is broken into three four-week units on Ecology, Cells, and Genetics. Students work in groups to design experiments and write lab reports.
General Biology is a majors course that uses in-class problem-solving to give students a firm foundation in biology as a preparation for future science courses. Units include Ecology, Cells, Genetics, Evolution and Populations. The lab is broken into three four-week units on Ecology, Cells, and Genetics. Students work in groups to design experiments and write lab reports.
Molecular Biology lecture consists of four sections. In the first we look at the central dogma and regulation of gene expression. Next we focus on basic biotechnology techniques by examining the cloning and expression of human tissue plasminogen activator. In the next section the course we examine cellular processes including cancer, developmental biology and the production of transgenic and cloned animals. Finally we explore the role of proteomics and genomics in elucidating the function of BRCA1.In Molecular Biology Lab students work on two projects that are part of the research programs of other faculty in biochemistry or cell and molecular biology. This allows the students to participate in a real research experiment. This also exposes them to several aspects of biotechnology research; yeast-two hybrid screening, site directed mutagenesis, cloning, and computer modeling. The students write their results in a peer-reviewed journal format.
Bioinformatics is a team taught course that focuses on the many applications of bioinformatics and the theoretical algorithms underlying these computer programs. There are four sections to the course; Databases, Phylogenetics, Genomics and Proteomics.
Molecular Basis of Disease and Drug Action examines the biological basis of many non-infectious and non-cancerous diseases and the drugs used to treat them. For each disease the students are given three perspectives; pathology, pharmacology and clinical. This course is team taught by Scott Cooper (pathology), Aaron Monte (pharmacology) and several M.D.s from local hospitals (clinical). There are five units in the course; Pathology and Pharmacology, Inflammation, Cardiovascular, Neurological, and Genetics. Students also give oral presentations on assigned diseases.
Radiation Biology is a course primarily for nuclear medical technology (NMT) and radiation therapy (RT) majors. It focuses on the effects of radiation on biological systems. The lab involves both exploring the properties of radiation, and the effects of radiation on biomolecules and cells.
Structure function studies of anticoagulants: Uses of molecular tools in environmental sciences
My students are working on several projects related to understanding blood clotting
My students have worked on several projects in collaboration with faculty in the River Studies Program at UWL. Many of these use techniques used in medical diagnostics and forensics.
DNA sequence identification of an aquatic slug (Arion fasciatus). Rick Gillis and Roger Haro.
Detection of the trout parasite responsible for whirling disease (Myxobolus cerebralis) in Wisconsin. Dan Sutherland Development of a PCR-based test for the perch parasite Heterosporis. Dan Sutherland.
Graduate Student Theses:
Published Peer Reviewed Journal Articles:
Patrick R. Gonzales, Timothy D. Walston, Laureano O. Camacho, Dana M. Kielar, Frank C. Church, Alireza R. Rezaie, Scott Cooper. Mutation of the H-helix in Antithrombin Decreases Heparin Stimulation of Protease Inhibition. BBA Proteins and Proteomics, 1774 (11), pp 1431-1437, 2007.
Fortenberry YM, Whinna HC, Cooper ST, Myles T, Leung LL, Church FC. Essential thrombin residues for inhibition by protein C inhibitor with the cofactors heparin and thrombomodulin. J Thromb Haemost, 5(7):1486-92, 2007.
Scott Cooper, Robin Tyser, Mark Sandheinrich. The Benefits of Linking Assignments to Online Quizzes in Introductory Biology Courses. Journal of Online Learning and Teaching, Vol. 3, No.3, pp. 214-221, 2007.
Glasscock, L.N., S.M. Rehault, C.W.
Gregory, Cooper, S.T., Jackson, T.P., Hoffman, M., and F.C. Church. Protein C inhibitor (Plasminogen Activator Inhibitor-3)
expression in the CWR22 prostate cancer xenograft.
Exp. Molec. Pathol.
R.J. Haro, R. Gillis and S. T. Cooper. First Report of a Terrestrial Slug (Arion fasciatus) Living in an Aquatic Habitat. Journal of Malacologia. 45; 2004.
Likui Yang, Chandrashekhara Manithody, Timothy D. Walston, Scott T. Cooper, and Alireza R. Rezaie. Thrombomodulin enhances the reactivity of thrombin with protein C inhibitor by providing both a binding-site for the serpin and allosterically modulating the activity of thrombin. J. Biol. Chem. 278; p. 37465-37470, 2003.
Laura N. Glasscock, Bruce Gerlitz, Scott T. Cooper, Brian W. Grinnell and Frank C. Church. Basic residues in the 37-loop of activated protein C modulate inhibition by protein C inhibitor but not by 1-antitrypsin, BBA - Proteins and Proteomics 1649; 106-117, 2003.
Jackson, T.P., Cooper, S.T. and Church, F.C. Assessment of the Protein C Inhibitor-Urokinase Interaction. J Protein Chem 16: 819-828, 1997.
Cooper, S.T., Neese, L.L., Dicuccio, M., Liles, D.K., Hoffman, M. and Church, F.C. Heparin-binding Serpins are not Released Following Intravenous Heparin Injection. Clinical and Applied Thrombosis/Hemostasis 2: 185-191, 1996.
Cooper, S.T., Whinna, H.C., Jackson, T.P. and Church, F.C. Intermolecular Interactions Between Protein C Inhibitor and Coagulation Proteases. Biochemistry 34, 12991-12997, 1995.
Rezaie, A.R., Cooper, S.T., Church, F.C., and Esmon, C.T. Protein C Inhibitor is a Potent Inhibitor of the Thrombin-thrombomodulin Complex. J. Biol. Chem 270: 25336-9, 1995.
Cooper, S.T. and Church, F.C. Reactive Site Mutants of Recombinant Protein C Inhibitor. Biochim. Biophys. Acta 1246. 29-33, 1995.
Hoffman, M. and Cooper, S.T. Thrombin Enhances Monocyte Secretion of Tumor Necrosis Factor and Interleukin-1 by Two Distinct Mechanisms. Blood Cells, Molecules and Diseases 21: 156-167, 1995.
Phillips, J.E., Cooper, S.T., Potter, E.E. and Church, F.C. Mutagenesis of Recombinant Protein C Inhibitor Reactive Site Residues Alters Target Proteinase Specificity. J. Biol. Chem. 26: 16696-16700, 1994.
Cooper, S.T. and Attie, A.D. Apolipoprotein R: A new member of the short consensus repeat family of proteins. Biochemistry 31: 12328-12336, 1992.
Cooper, S.T., Aiello, R.J., Checovich, W.J. and Attie, A.D. Low density lipoprotein heterogeneity in spontaneously hypercholesterolemic pigs. Mol. Cell. Biochem. 113: 133-140, 1992.
Published Non-Peer Reviewed Articles:
Cooper, S.T. Integrating bioinformatics into undergraduate courses. Biochemistry and Molecular Biology Education 29:167-168, 2001
Cooper, S.T. and Church, F.C. PCI: Protein C Inhibitor? Adv Exp Med Biol 425: 45-54, 1997.
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