Year hired: 2000
University of Illinois, Champaign-Urbana, 1988. B.S. Biology
(Liberal Arts &Sciences)
University of Wisconsin - Madison, 1994. Ph.D. Molecular Biology
University of Wisconsin - Madison, 1994-95. Postdoctoral Fellow
Cleveland Clinic, Department of Molecular Biology, 1995-99. Postdoctoral Fellow
Virology and Virology Lab (MIC 420, MIC 421)
Global Impact of Infectious Disease (MIC 130)
Fundamentals of Microbiology Lab (MIC 230)
Microbes and Society Lab (MIC 100)
Immunology Lab (MIC 406)
Research in my laboratory focuses on two areas of virology - the replication of human parainfluenza virus type 3 (HPIV3) and the characterization of novel fish viruses.
Human parainfluenza virus type 3 infects children, causing lower respiratory tract infections such as croup, pneumonia and bronciolitus. There are no effective vaccines or antiviral therapies. My particular research interests focus on the process through which virus particles are assembled and released from infected cells. Knowledge gained from this research can be applied to the development of vaccines and antiviral drugs against HPIV3. I currently have an NIH AREA grant entitled “Characterization of Human Parainfluenza Virus Type 3 Assembly and Release” to fund this research. For the characterization of novel fish viruses my lab collaborates with the U.S. Fish and Wildlife Service - Fish Health Laboratory to characterize viruses that they have isolated, but are unable to identify. For both areas of research, we use a variety of techniques from molecular biology, biochemistry and immunology.
Fishing, Biking, Racquetball, Coaching Youth Sports
Marisa Barbknecht, Sol Sepsenwol, Eric Leis, Maren Tuttle-Lao, Mark Gaikowski, Susan E. Kelly, Nick J. Knowles, Becky Lasee, Michael A. Hoffman. 2013. Characterization of a new picornavirus isolated from the freshwater fish Lepomis macrochirus. Submitted to Journal of Virology.
Gander, J.R., L.M. Schwan and M.A. Hoffman. 2011. Analysis of nucleotides 13-96 of the human parainfluenza virus type 3 antigenomic promoter reveals positive- and negative-acting replication elements. Virology, 419(2), 90-96.
Hoffman, M.A, L.M Thorson, J.E. Vickman, J.S. Anderson, N.A. May and M.N. Schweitzer. 2006. Roles of human parainfluenza virus type 3 bases 13 to 78 in replication and transcription: Identification of an additional replication promoter element and evidence for internal transcription initiation. Journal of Virology. 80:5388-96.
Malur A.G., M.A.Hoffman and A.K. Banerjee. The human parainfluenza virus type 3 (HPIV 3) C protein inhibits viral transcription. 2004. Virus Res. 99(2):199-204.
Hoffman MA, Banerjee AK. Precise mapping of the replication and transcription promoters of human parainfluenza virus type 3. Hoffman MA, Banerjee AK. Virology. 2000 Mar 30;269(1):201-11.