William (Bill) Schwan

Professor

Year hired: Fall 1998

 

picture of Bill Schwan

Education:

Quincy College, B.S. Biology
Iowa State University, M.S. Microbiology
Northwestern University, Ph.D. Microbiology and Immunology
Postdoc: Univ. Wurzburg, Wurzburg, Germany
     FDA, Bethesda, MD

Courses taught:

Pathogenic Bacteriology (MIC 407/507)
Mechanisms of Microbial Pathogenesis (MIC 454/554)
Fundamentals of Microbiology Lab (MIC 230)

Research Interests:

I am currently working on three divergent projects.

1) Regulation of type 1 pilus expression in uropathogenic Escherichia coli.  I am using molecular, genetic, and animal model techniques to try to elucidate how type 1 pilus expression is regulated in E. coli that cause urinary tract infections in humans.

2) Evolution and virulence of community-associated methicillin-resistant S. aureus (CA-MRSA).  I am part of the larger group with Marshfield Clinic exploring how CA-MRSA may have evolved using molecular techniques and what makes this subgroup of S. aureus such a major health problem through the use of genetics, molecular techniques, and animal models of infection.

3) The use of plants and mushrooms to try to discover new antimicrobial agents.  I am part of a larger group called Mycophyte Discovery that is isolating anti-microbial agents.  This is a cross-disciplinary project involving microbiologists, biologists, and chemists.  We have two patent applications pending.

Currently, I have funding from the NIH and UW-System for all three projects.

Recent Publications:

Schwan, W. R.   2008.  Flagella allow uropathogenic Escherichia coli ascension into murine kidneys.  Int. J. Med. Microbiol. 298:441-447.

Schwan, W. R., S. Shibata, S.-I. Aizawa,  and A. Wolfe.  2007.  The two-component response regulator RcsB regulates type 1 piliation in Escherichia coli.  J. Bacteriol. 189:7159-7163.

Gilmore, G. D., W. R. Schwan, and M. K. McLaughlin.  2007.  An assessment of emergency preparedness in Western Wisconsin.   WMJ. 106:71-77.

Cantlon, C. A., M. E. Stemper, W. R. Schwan, M. A. Hoffman, and S. S. Qutaishat.  2006.  Significant pathogens isolated from surgical site infections at a community hospital in the Midwest.  Am. J. Infect. Control  34:526-529.

Burgess, J. W.*, W. R. Schwan, and T. J. Volk.  2006.  PCR-based detection of DNA from the human pathogen Blastomyces dermatitidis from natural soil samples.  Med. Mycol. 44:741-748.

Schwan, W. R., L. Lehmann*, and J. McCormick.  2006.  Transcriptional activation of the Staphylococcus aureus putP gene by low-proline-high osmotic conditions and during  infection of murine and human tissues.   Infect. Immun. 74:399-409.

Schwan, W. R., M. T. Beck*, S. J. Hultgren, J. Pinkner, N. L. Woolever*, and T. Larson*.  2005.  Down-regulation of the kps region 1 capsular assembly operons following attachment of Escherichia coli type 1 fimbriae to D-mannose receptors.  Infect. Immun. 73:1226-1231.

Schwan, W. R.  P. Warrener, E. Keunz*, C. K. Stover, and K. R. Folger. 2005.  Mutations in the cueA gene, encoding a copper homeostasis P-type ATPase, reduce the pathogenicity of Pseudomonas aeruginosa in mice.  Int. J. Med. Microbiol. 295:237-242.
* = student author

Patents:
Monte, A.; M. Rott, L. Defoe, and W. R. Schwan.  “Anti-Infective Agents and Methods of Use,”U.S.Patent Application #T04013US, accepted by the U.S. Patent and Trademark Office, April 27, 2006.

Cook, J. M., L. Defoe, M. S. Kabir, A. Monte, M. Rott, and W. R. Schwan.  T07042US CIP Application (Derivative of T04013US): Anti-infective Agents and Methods of Use, filed with the U.S. Patent and Trademark Office, April 6, 2007.

Schwan, W. R., A. Monte, M. Rott, and T. Volk. T04010US: Treatment of Microbial Infections and methods of use, filed as a patent with the U.S. Patent and Trademark Office, Aug. 28, 2008.

Recent Student Presentations:
Engelbrecht, K., M. Kabir, J. Cook, A. Monte, M. Rott, and W. Schwan.  2007.  Antibacterial activity of (E)-3-methoxy-5-hydroxy-stilbene and analogs against clinically significant Gram-positive bacteria. 67thAnnual North Central Branch American Society for Microbiology meeting, Marshfield, WI.

Bretl, D., and W. Schwan.  2007.  Regulation of the superantigen-like protein 1 of community-associated methicillin-resistant Staphylococcus aureus. 67th Annual North Central Branch American Society for Microbiology meeting, Marshfield, WI.

Dahlke, S., and W. Schwan.  2007.  Construction of recombinant plasmids containing ear and sec4. 67th Annual North Central Branch American Society for Microbiology meeting, Marshfield, WI.

Engelbrecht, K., W. R. Schwan, A. Monte, T. Volk, and M. Rott.  2007.  Screening a fungal fruiting body library for antimycobacterial activity.  107th Annual Meeting of the American Society for Microbiology Meeting, Toronto, ON.

Westphal, M. E., J. M. Brady, N. Moore, R. K. Bickford, S. K. Shukla, and W. R. Schwan.   2006.  Differences in toxin and adherence factor gene profiles in community-associated methicillin-resistant Staphylococcus aureus and methicillin-sensitive S. aureus isolates.  66th Annual Meeting of the North Central Branch of the American Society for Microbiology,  Oct. 20-21, Brookings, SD.

Bickford, R., M. Westphal, J. Brady, S. Shukla, and W. R. Schwan.  2006.  Gene detection in Staphylococcus aureus. 66th Annual Meeting of the North Central Branch of the American Society for Microbiology,  Oct. 20-21, Brookings, SD.

Sleger, C., K. Engelbrecht, W. Schwan, and M. Rott.  2006.  Screening fungal fruiting bodies for anti-mycobacterial activity. 66th Annual Meeting of the North Central Branch of the American Society for Microbiology,  Oct. 20-21, Brookings, SD.