ADJUNCT FACULTY

Gundersen Health System

The Gundersen Health System Laboratory Research

Arick P Sabin, DO, MPH, D(ABMM), Division of Infectious Disease, Wound Care and Hyperbaric Medicine

Dr. Sabin's research interests include molecular microbiology, zoonotic diseases, fungal diseases, and microbiology diagnostics. Clinically, he has a strong interest in HIV and fungal infections.

Recent Publications:

Widespread Lichtheimia Infection in a Patient with Extensive Burns: Opportunities for Novel Antifungal Agents. Thielen BK, Barnes AMT, Sabin AP, Huebner B, Nelson S, Wesenberg E, Hansen GT. Mycopathologia. 2019 Feb;184(1):121-128.

Mycobacterium abscessus Complex Infections in Children: A Review. Sabin AP, Ferrieri P, Kline S.Curr Infect Dis Rep. 2017 Oct 5;19(11):46.

 

Steven M. Callister, Ph.D., Section of Infectious Diseases and Microbiology Research 

Dr. Callister is a senior research scientist in the Microbiology Research Laboratory. Dr. Callister’s research focuses on pathogenesis and immune responses during infections with spirochetal bacteria.

Recent publications:

Snyder JL, Giese H, Bandoski-Gralinski C, et al. T2 Magnetic Resonance Assay-Based Direct Detection of Three Lyme Disease-Related Borrelia Species in Whole-Blood Samples. J Clin Microbiol. 2017;55(8):2453–2461. 

Jobe DA, Lovrich SD, Oldenburg DG, Kowalski TJ, Callister SM. Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014-2015. Emerg Infect Dis. 2016;22(8):1471–1473. 

LaFleur RL, Callister SM, Dant JC, Wasmoen TL, Jobe DA, Lovrich SD. Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease. Clin Vaccine Immunol. 2015;22(7):836–839. 

Denys GA, Callister SM, Dowzicky MJ. Antimicrobial susceptibility among gram-negative isolates collected in the USA between 2005 and 2011 as part of the Tigecycline Evaluation and Surveillance Trial (T.E.S.T.). Ann Clin Microbiol Antimicrob. 2013 Sep 5;12:24.

Arnaboldi PM, Seedarnee R, Sambir M, Callister SM, Imparato JA, Dattwyler RJ. Outer surface protein C peptide derived from Borrelia burgdorferi sensu stricto as a target for serodiagnosis of early lyme disease. Clin Vaccine Immunol. 2013 Apr;20(4):474-81.

 

Dean A. Jobe, M.S., RM(AAM), Microbiology Research Laboratory

Dean Jobe is the supervisor of the Microbiology Research Laboratory. His research focuses on antibody responses during bacterial infections and development of diagnostic tests.

Recent publications:

Jobe DA, Lovrich SD, Oldenburg DG, Kowalski TJ, Callister SM. Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014-2015. Emerg Infect Dis. 2016;22(8):1471–1473. 

LaFleur RL, Callister SM, Dant JC, Wasmoen TL, Jobe DA, Lovrich SD. Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease. Clin Vaccine Immunol. 2015;22(7):836–839. 

Go RS, Lee SJ, Shin D, Callister SM, Jobe DA, Conry RM, Tarhini AA, Kirkwood JM. ECOG Phase II Trial of Graded-Dose Peginterferon α-2b in Patients with Metastatic Melanoma Overexpressing Basic Fibroblast Growth Factor (E2602). Clin Cancer Res. 2013 Dec 1;19(23):6597-604.

 

Steven D. Lovrich, Ph.D., Microbiology Research Laboratory

Dr. Lovrich is a molecular biologist in the Microbiology Research Laboratory. His research focuses on identification, purification, and characterization of bacterial protein vaccine candidates.

Recent publications:

Jobe DA, Lovrich SD, Oldenburg DG, Kowalski TJ, Callister SM. Borrelia miyamotoi Infection in Patients from Upper Midwestern United States, 2014-2015. Emerg Infect Dis. 2016;22(8):1471–1473.

LaFleur RL, Callister SM, Dant JC, Wasmoen TL, Jobe DA, Lovrich SD. Vaccination with the ospA- and ospB-Negative Borrelia burgdorferi Strain 50772 Provides Significant Protection against Canine Lyme Disease. Clin Vaccine Immunol. 2015;22(7):836–839. 

Rentschler AE, Lovrich SD, Fitton R, Enos-Berlage J, Schwan WR. OmpR regulation of the uropathogenic Escherichia coli fimB gene in an acidic/high osmolality environment. Microbiology. 2013 Feb;159(Pt 2):316-27

Shukla SK, Pantrangi M, Stahl B, Briska AM, Stemper ME, Wagner TK, Zentz EB, Callister SM, Lovrich SD, Henkhaus JK, Dykes CW. Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality. J Clin Microbiol. 2012 Nov;50(11):3526-33.

 

Douglas White, M.D., Ph.D, Rheumatology

Dr. White is the chief of the Rheumatology Section at Gundersen Lutheran and Dr. Oldenburg is a faculty member at UW-La Crosse. Together they run the rheumatology research lab studying the interactions between latent herpesviruses and their hosts' immune systems.

Recent publications:

Dong Q, Smith KR, Oldenburg DG, et al. Combinatorial Loss of the Enzymatic Activities of Viral Uracil-DNA Glycosylase and Viral dUTPase Impairs Murine Gammaherpesvirus Pathogenesis and Leads to Increased Recombination-Based Deletion in the Viral Genome. mBio. 2018;9(5):e01831-18. Published 2018 Oct 30. 

Niemeyer BF, Oko LM, Medina EM, et al. Host Tumor Suppressor p18^INK4c Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. J Virol. 2018;92(6):e01604-17. Published 2018 Feb 26. 

Van Skike ND, Minkah NK, Hogan CH, et al. Viral FGARAT ORF75A promotes early events in lytic infection and gammaherpesvirus pathogenesis in mice [published correction appears in PLoS Pathog. 2018 Sep 25;14(9):e1007319]. PLoS Pathog. 2018;14(2):e1006843. Published 2018 Feb 1. 

Minkah N, Macaluso M, Oldenburg DG, et al. Absence of the uracil DNA glycosylase of murine gammaherpesvirus 68 impairs replication and delays the establishment of latency in vivo. J Virol. 2015;89(6):3366–3379. 

White DW, Suzanne Beard R, Barton ES. Immune modulation during latent herpesvirus infection. Immunol Rev. 2012 Jan;245(1):189-208

  

Marshfield Clinic / St. Joseph’s Hospital

All of the Marshfield faculty are part of the Marshfield Clinic Research Institute

Thomas R. Fritsche, M.D., Ph.D., Division of Laboratory Medicine, Clinical Microbiology Section

Dr. Fritsche has worked in the fields of diagnostic clinical microbiology, parasitology, antimicrobial susceptibility testing and resistance emergence. Collaborations have involved the study of novel bacterial endosymbionts occurring within free-living amoebae, and the role of protozoa as professional phagocyte mimics. Such evolutionary relationships may have implications for the preadaption and/or recruitment of recognized intracellular pathogens such as the Chlamydiales and Rickettsiales for metazoan hosts. 

Schotthoefer AM, Meece JK, Ivacic LC, Bertz PD, Zhang K, Weiler T, Uphoff TS, Fritsche TR. Comparison of a real-time PCR method with serology and blood smear analysis for diagnosis of human anaplasmosis: importance of infection time course for optimal test utilization. J Clin Microbiol. 2013 Jul;51(7):2147-53.

Lin Y, Barker E, Kislow J, Kaldhone P, Stemper ME, Pantrangi M, Moore FM, Hall M, Fritsche TR, Novicki T, Foley SL, Shukla SK. Evidence of multiple virulence subtypes in nosocomial and community-associated MRSA genotypes in companion animals from the upper midwestern and northeastern United States. Clin Med Res. 2011 Mar;9(1):7-16

Fritsche TR, Biedenbach DJ, Jones RN. 2009 Antimicrobial activity of prulifloxacin tested against a worldwide collection of gastroenteritis-producing pathogens, including those causing traveler's diarrhea. Antimicrob Agents Chemother. Mar;53(3):1221-4.

 

Jennifer Meece, Ph.D., Clinical Research

Dr. Meece is a vector biologist in the Clinical Research Center at Marshfield Clinic Research Foundation. Her research interests include the genetics of infectious disease transmission in mosquitoes and the ecology of infectious diseases.

Recent publications:

McLean HQ, Meece JK, Belongia EA. Influenza vaccination and risk of hospitalization among adults with laboratory confirmed influenza illness. Vaccine. 2013 Nov 26.

Sundaram ME, Meece JK, Sifakis F, Gasser RA Jr, Belongia EA. Medically Attended Respiratory Syncytial Virus Infections in Adults Aged >=50 Years: Clinical Characteristics and Outcomes. Clin Infect Dis. 2013 Dec 19.

Hanincova K, Mukherjee P, Ogden NH, Margos G, Wormser GP, Reed KD, Meece JK, Vandermause MF, Schwartz I. Multilocus sequence typing of Borrelia burgdorferi suggests existence of lineages with differential pathogenic properties in humans. PLoS One. 2013 Sep 17;8(9)

Kjos SA, Irving SA, Meece JK, Belongia EA. Elementary school-based influenza vaccination: evaluating impact on respiratory illness absenteeism and laboratory-confirmed influenza. PLoS One. 2013 Aug 26;8(8)

Sundaram ME, McClure DL, VanWormer JJ, Friedrich TC, Meece JK, Belongia EA. Influenza vaccination is not associated with detection of noninfluenza respiratory viruses in seasonal studies of influenza vaccine effectiveness. Clin Infect Dis. 2013 Sep;57(6):789-93.

Schotthoefer AM, Meece JK, Ivacic LC, Bertz PD, Zhang K, Weiler T, Uphoff TS, Fritsche TR. Comparison of a real-time PCR method with serology and blood smear analysis for diagnosis of human anaplasmosis: importance of infection time course for optimal test utilization. J Clin Microbiol. 2013 Jul;51(7):2147-53

Anderson JL, Sloss BL, Meece JK. Clinical and molecular epidemiology of veterinary blastomycosis in Wisconsin. BMC Vet Res. 2013 Apr 22;9:84

 

Mary Stemper, M.S., Clinical Microbiology and Clinical Research 

Mary is a molecular epidemiologist at Marshfield Clinic. Her research interests include the epidemiology of nosocomial pathogens, particularly investigations of methicillin-resistant Staphylococcus aureus and the detection of clinical pathogens based on the analysis of the 16S rRNA gene. 

Recent Publications:

Shukla SK, Pantrangi M, Stahl B, Briska AM, Stemper ME, Wagner TK, Zentz EB, Callister SM, Lovrich SD, Henkhaus JK, Dykes CW. Comparative whole-genome mapping to determine Staphylococcus aureus genome size, virulence motifs, and clonality. J Clin Microbiol. 2012 Nov;50(11):3526-33.

Pearce MM, Theodoropoulos N, Noskin GA, Flaherty JP, Stemper ME, Aspeslet T, Cianciotto NP, Reed KD. Native valve endocarditis due to a novel strain of Legionella. J Clin Microbiol. 2011 Sep;49(9):3340-2. 

Lin Y, Barker E, Kislow J, Kaldhone P, Stemper ME, Pantrangi M, Moore FM, Hall M, Fritsche TR, Novicki T, Foley SL, Shukla SK. Evidence of multiple virulence subtypes in nosocomial and community-associated MRSA genotypes in companion animals from the upper midwestern and northeastern United States. Clin Med Res. 2011 Mar;9(1):7-16

  

Wisconsin State Laboratory of Hygiene

Pete Shult, Ph.D., Communicable Disease Division

Dr. Schult is Director of the Communicable Diseases Division and Emergency Laboratory Response. He also serves as statewide coordinator for laboratory response to bioterrorism and pandemic influenza planning.

Recent publications:

Van TT, Miller J, Warshauer DM, Reisdorf E, Jernigan D, Humes R, Shult PA. Pooling nasopharyngeal/throat swab specimens to increase testing capacity for influenza viruses by PCR. J Clin Microbiol. 2012 Mar;50(3):891-6.

Kirk CJ, Shult PA. Developing laboratory networks: a practical guide and application. Public Health Rep. 2010 May-Jun;125 Suppl 2:102-9.

Laplante JM, Marshall SA, Shudt M, Van TT, Reisdorf ES, Mingle LA, Shult PA, St George K. Influenza antiviral resistance testing in new york and wisconsin, 2006 to 2008: methodology and surveillance data. J Clin Microbiol. 2009 May;47(5):1372-8

Dharan NJ, Gubareva LV, Meyer JJ, Okomo-Adhiambo M, McClinton RC, Marshall SA, St George K, Epperson S, Brammer L, Klimov AI, Bresee JS, Fry AM; Oseltamivir-Resistance Working Group. Infections with oseltamivir-resistant influenza A(H1N1) virus in the United States. JAMA. 2009 Mar 11;301(10):1034-41.

Gern JE, Brooks GD, Meyer P, Chang A, Shen K, Evans MD, Tisler C, Dasilva D, Roberg KA, Mikus LD, Rosenthal LA, Kirk CJ, Shult PA, Bhattacharya A, Li Z, Gangnon R, Lemanske RF Jr. 2006. Bidirectional interactions between viral respiratory illnesses and cytokine responses in the first year of life. J Allergy Clin Immunol. Jan;117(1):72-8. 

 

Dave Warshauer, Ph.D., Communicable Disease Division

Dr. Warshauer is Chief Bacteriologist for the Communicable Diseases Division and coordinates molecular and other diagnostic test development for agents of public health importance including bioterrorism.

Recent publications: 

Van TT, Miller J, Warshauer DM, Reisdorf E, Jernigan D, Humes R, Shult PA. Pooling nasopharyngeal/throat swab specimens to increase testing capacity for influenza viruses by PCR. J Clin Microbiol. 2012 Mar;50(3):891-6. 

Feltus DC, Giddings CW, Schneck BL, Monson T, Warshauer D, McEvoy JM. 2006. Evidence supporting zoonotic transmission of Cryptosporidium in Wisconsin. J Clin Microbiol. 2006 Sep 27; [Epub ahead of print] 

Okwumabua O, O'Connor M, Shull E, Strelow K, Hamacher M, Kurzynski T, Warshauer D. 2005. Characterization of Listeria monocytogenes isolates from food animal clinical cases: PFGE pattern similarity to strains from human listeriosis cases. FEMS Microbiol Lett. Aug 15;249(2):275-81. 

 

Bob Garrison, D.V.M., M.S., Communicable Disease Division

Dr. Garrison directs Division Operations, the laboratory’s zoonotic diseases program. In addition, he assists the Director of the Communicable Disease Division in emergency laboratory response and planning.