Aaron Monte

Professor
Chemistry And Biochemistry
Office hours
4001 Cowley Hall
608.785.8260
amonte@uwlax.edu

Specialty area(s)

Organic / Medicinal / Natural Products Chemistry, Psychopharmacology

Brief biography

Dr. Monte has designed and synthesized several potent and selective drugs used to map the molecular structural features of serotonin 5-HT2 receptor proteins in the human central nervous system. He also has been involved in isolating and identifying chemical constituents from wild fungi and traditional herbal remedies used by indigenous American cultures for use as new drug therapies, especially anti-infectives. Dr. Monte was co-founder of the UWL Undergraduate Research Program and served as chair of the first URC (1998-2000) and editor-In-chief of the UWL Journal of Undergraduate Research (1998-2011). He has served as a faculty senator, chaired several university committees, been involved in the hiring of many faculty and administrative colleagues, and won awards for both teaching and research. One of his main passions is serving as chair of the UWL Department of Chemistry & Biochemistry and helping its faculty and students be the best they can be.

Current courses at UWL

BIO 443/543 - Molecular Mechanisms of Disease & Drug Action, aka "Drugs and Disease" (Spring)

Teaching history

PAS 630 - Medical Pharmacology & Pharmacotherapeutics

BIO 443/543 - Molecular Mechanisms of Disease & Drug Action

CHM 471 - Capstone in Chemistry & Biochemistry

CHM 305 - Organic Chemistry Laboratory

CHM 304 - Organic Chemistry Theory II

CHM 303 - Organic Chemistry Theory I

CHM 300/300L - Survey of Organic Chemistry Lecture & Laboratory

CHM 250 - Introduction to Organic Chemistry & Biochemistry

PHY 106 - Physical Science for Educators

CHM 103L - General Chemistry Laboratory

CHM 100/100L - Contemporary Chemistry Lecture & Laboratory

 

Professional history

2015-Present, Sr Academic Planner/Faculty Assistant to the Provost

2011-Present, Director, UWL Emerging Technology Center in Pharmaceutical Development

2004-Present, Department Chairperson

2003-Present, Professor of Chemistry & Biochemistry

1998-Present, Member of the Graduate Faculty

1998-2003, Associate Professor of Chemistry

1995-1998, Assistant Professor of Chemistry

Research and publishing

* = undergraduate co-author

Schwan, W. R.; Polanowski, R.; Dunman, P. M.; Medina-Bielski, S.*; Lane, M.*; Rott, M.; Lipker, L.*; Monte, A.; Cook, J. M.; Somerville, G. A.; Mikel, C.*; Kabir, M. S., “Identification of Staphylococcus aureus cellular pathways affected by the stilbenoid lead drug, SK-03-92, using a microarray.” Submitted to Antibiotics, July 2017

Huang, C-C., Monte, A., "SKIN-LIGHTENING COMPOUNDS," US Patent Application Publication, Pub. No. US 2017/0197897 A1, July 13, 2017.

Huang, C-C., Monte, A., "A-11, A POTENTIAL SAFER AND BETTER SKIN-WHITENING AGENT," US Utility Patent Application (WiSys Ref # T140007US02), Filed with the U.S. Patent and Trademark Office on January 20, 2017.

Stueven, N.*, Monte, A., Hwang, S-P. L., Huang, C-C., “A11 Part I: Novel Stilbene-like Compounds That Reduce Melanin Through Inhibiting Melanocyte Differentiation and Proliferation Without Inhibiting Tyrosinase.”  Submitted to Pigment Cell and Melanoma Research, Dec 2016Under review

Martinson, K.,** Stueven, N.**, Monte, A., Huang, C-C., “A11 Part I: Novel Stilbene-like Compounds That Reduce Melanin Through Inhibiting Melanocyte Differentiation and Proliferation Without Inhibiting Tyrosinase.”  Submitted to Pigment Cell and Melanoma Research, Dec 2016Under review.

Huang, C-C., Monte, A., "CANCEROUS CELL GROWTH INHIBITING COMPOUNDS," U.S. Provisional Patent Application (WiSys Ref # T160035US01), U.S. Patent and Trademark Office, Applied for April 7, 2016

Huang, C-C., Monte, A., "A-11, A POTENTIAL AND BETTER SKIN-WHITENING AGENT," Patent Cooperation Treaty (PCT) Application (WiSys Ref # T140007WO), Filed with the World Intellectual Property Organization (WIPO) on July 21, 2015.

Witzigmann, C. M., Tiruveedhula, V.V.N.P.B., Cook, J. M., Schwan, W. R., Rott, M. A., Monte, A., "COMPOUNDS FOR THE TREATMENT OF GRAM-POSITIVE BACTERIAL INFECTIONS, INCLUDING DRUG RESISTANT STRAINS OF STAPHYLOCOCCUS AUREUS," U.S. Provisional Patent Application No. 61/975,396, (Atty. File No. 020871-9097-US00), U.S. Patent and Trademark Office, Applied for April 4, 2014.

Huang, C-C., Monte, A., Cook, J. M., Shahjahan, K. M., Peterson, K. P. “Zebrafish Heart Failure Models for the Evaluation of Chemical Probes and Drugs.” ASSAY and Drug Development Technologies, 2013, 11 (9-10), 561-572.

Tiruveedhula, V.V.N.P.B., Witzigmann, C. M., Verma, R., Kabir, M. S., Rott, M., Schwan, W. R., Medina-Bielski, S.*, Lane, M.*, Close, W.*, Polanowski, R. L., Sherman, D., Monte, A., Cook, J. M., Design and synthesis of novel antimicrobials with activity against Gram-positive bacteria and mycobacterial species, including M. tuberculosis, Bioorg. Med. Chem., 2013, 21, 7830-7840.

Kabir, M. S., Cook, J. M., Monte, A. P., Rott, M. A., Schwan, W. R., Witzigman, C. M., Namjoshi, O. A., Tiruveedhula, V.V.N.P.B., Verma, R. S., "DESIGN AND SYNTHESIS OF ACRYLATE ESTERS WITH ACTIVITY AGAINST BACTERIA AND MYCOBACTERIA, INCLUDING M. TUBERCULOSIS AND METHICILLIN RESISTANT S. AUREUS (MRSA)," U.S. Provisional Patent Application, 106 pages with tables and figures, U.S. Patent and Trademark Office, Applied for April 10, 2013.

Wang, Q., Song, F., Xiao, X., Huang, P., Li, L., Monte, A., Abdel-Mageed, W. M., Wang, J., Guo, H., He, W., Xie, F., Dai, H., Liu, M., Chen, C., Xu, H., Liu, M., Piggott, A. M., Liu, X. T., Capon, R. J., Zhang, L. “Abyssomicins from the South China Sea Deep-Sea Sediment Verrucosispora sp.: Natural Thioether Michael Addition Adducts as Antitubercular Prodrugs.” Angewandte Chemie, Int. Ed., 2013, 52, 1231-1234.

Liu, X. T., Schwan, W. R., Volk, T. J., Rott, M. A., Liu, M., Huang, P., Liu, Z., Wang, Y. Zitomer, N. C., Sleger, C.*, Hartsel, S. A., Monte, A., Zhang, L. “Antibacterial Spirobisnaphthalenes from the North American Cup Fungus Urnula craterium.” J. Nat. Prod., 2012, 75, 1534-1538.

Monte, A. P., Kabir, M. S., Cook, J. M., Monte, A. P., Rott, M. A., Schwan, W. R., Witzigman, C. M., Namjoshi, O. A., Tiruveedhula, V.V.N.P.B., Verma, R. S., "STEREOSPECIFIC SYNTHESIS OF ACRYLATE ETHERS AND AMINES FOR INDUSTRIAL AND MEDICINAL APPLICATIONS," U.S. Provisional Patent Application, 97 pages with tables and figures, U.S. Patent and Trademark Office, Applied for March 14, 2012.

Kabir, M. S.; Namjoshi, O. A.; Verma, R.; Lorenz, M.; Tiruveedhula, V. V. N. P. B.; Monte, A.; Bertz, S. H.; Schwabacher, A. W.; Cook, J. M. “Bass Mediated Stereospecific Synthesis of Aryloxy and Amino Substituted Ethyl Acrylates.” J. Org. Chem., 2012, 77, 300-310.

Schwan, W. R.; Kabir, M. S.; Kallus, M.*; Krueger, S.*; Monte, A.; Cook, J. M. “Synthesis and Minimum Inhibitory Concentrations of SK-03-92 Against Staphylococcus aureus and Other Gram-Positive Bacteria.” J. Infect. Chemother., 2012, 18,124-126.

Monte, A.; Kabir, M. S.; Rott, M. A.; Schwan, W. R.; Cook, J. M., Miskowski, J. A. “BROAD SPECTRUM GRAM-POSITIVE ANTIMICROBIALS AND ANTHELMINTICS WITH EFFICACY AGAINST DRUG-RESISTANT STRAINS AND MYCOBACTERIUM SPECIES,” U.S. Non-Provisional Patent Application, Ser. #12/973,078: 106 pages with tables and figures, U.S. Patent and Trademark Office, Applied for December 20, 2010; accepted by USPTO, April 2011.

Kabir, M. S.; Namjoshi, O. A.; Verma, R.; Polanowski, R.*; Krueger, S. M.*; Sherman, D.; Rott, M. A.; Schwan, W. R.; Monte, A.; Cook, J. M. “A New Class of Potential Anti-Tuberculosis Agents: Synthesis and Preliminary Evaluation of Novel Acrylic Acid Ethyl Ester Derivatives.” Bioorg. Med. Chem., 2010, 18, 4178-4186.

Liu, X. T.; Winkler, A.*; Schwan, W. R.; Volk, T. J.; Rott, M. A.; Monte, A. “Antibacterial Compounds from Mushrooms II: Lanostane Triterpenoids and an Ergostane Steroid with Activity Against Bacillus cereus Isolated from Fomitopsis pinicola.” Planta Medica, 2010, 76, 464-466.

Schwan, W. R.; Dunek, C.*; Gebhardt, M.*; Engelbrecht, K.*; Klett, T.*; Monte, A.; Toce, J.; Rott, M. A.; Volk, T. J.; Li Puma, J. J.; Liu, X. T.; McKelvey, R. “Screening a Mushroom Extract Library for Activity Against Acinetobacter baumannii and Burkholderia cepacia Complex, and the Identification of a Compound with Anti-Burkholderia Activity.” Ann. Clin. Microbiol. Antimicrob., 2010, 9 (4),1-6.

Liu, X. T.; Winkler, A.*; Schwan, W. R.; Volk, T. J.; Rott, M. A.; Monte, A. “Antibacterial Compounds from Mushrooms I: Lanostane-type Triterpene and Prenylphenol Derivatives from Jahnoporus hirtus and Albatrellus flettii and their Activities Against Bacillus cereus.” Planta Medica, 2010, 76, 182-185.

Monte, A.; Kabir, M. S.; Ara, S.; Rott, M.; Schwan, W. R.; Cook, J. M.; “NEW AGENTS TO TREAT DRUG-RESISTANT GRAM-POSITIVE ANTIMICROBIAL INFECTIONS AS WELL AS ANTHRAX AND DRUG-RESISTANT TUBERCULOSIS,” U.S. Provisional Patent Application #T100005US: 46 pages with tables and figures, accepted by U.S. Patent and Trademark Office January 15, 2010.

Kabir, M. S.; Engelbrecht, K.*; Polanowski, R.*; Rott, M. A.; Schwan, W. R.; Stemper, M.; Reed, K.; Sherman, D.; Cook, J. M.; Monte, A. “New Classes of Gram-Positive Antibacterials: Inhibitors of MRSA and Surrogates of the Causative Agents of Anthrax and Tuberculosis.” Bioorg. Med. Chem. Lett., 2008, 18, 5745-5749.

Kabir, M. S.; Van Linn, M. L.; Monte, A.; Cook, J. M. “Stereo- and Regiospecific Synthesis of Vinyl Sulfides,” Synfacts, 2008, 10, 1089.

Kabir, M. S.; Van Linn, M. L.; Monte, A.; Cook, J. M. “Stereo- and Regiospecific Cu-Catalyzed Cross-Coupling Reaction of Vinyl Iodides and Thiols: A Very Mild and General Route for the Synthesis of Vinyl Sulfides.” Org. Lett., 2008, 10(15), 3363-3366.

Schultz, D. M.*; Prescher, J. P.*; Marona-Lewicka, D.; Kidd, S.; Nichols, D. E.; Monte, A. “’Hybrid’ Benzofuran/Benzopyran Congeners as Rigid Analogues of Hallucinogenic Phenethylamines.” Bioorg. Med. Chem., 2008, 16 (11), 6242-6251.

Whiteside, M. S.*; Kurrasch-Orbaugh, D.; Marona-Lewicka, D.; Nichols, D. E.; Monte, A. “Substituted Hexahydrobenzodipyrans as Serotonin 5-HT2A/2C Receptor Probes.” Bioorg. Med. Chem., 2002, 10, 3301-3306.

Monte, Aaron “Mentor Expectations and Student Responsibilities in Undergraduate Research.” Council on Undergraduate Research (CUR) Quarterly, 2001, 22 (2), 66-71.

Monte, A. P.; Marona-Lewicka, D.; Mayleben, M.; Mailman, R. B.; Nichols, D. E. “Substituted Naphthofurans as Hallucinogenic Phenethylamine-Ergoline Hybrid Molecules with Unexpected Muscarinic Antagonist Activity.” J. Med. Chem., 1998, 41, 2134-2145.

Monte, A. P.; Waldman, S. R.*; Marona-Lewicka, D.; Mayleben, M.; Mailman, R. B.; Wainscott, B.; Nelson, D. L.; Nichols, D. E. “Dihydrobenzofuran Analogues of Hallucinogens. 4. Mescaline Derivatives.” J. Med. Chem., 1997, 40, 2997-3008.

Waldman, S. R.*; Monte, A. P.; Bracey, A.*; Nichols, D. E. “One-Pot Claisen Rearrangement/O-Methylation/Alkene Isomerization in the Synthesis of Ortho-Methoxylated Phenylisopropylamines.” Tetrahedron Lett., 1996, 37, 7889-7892.

Nichols, David E.; Monte, A. P.; Huang, X.; Marona-Lewicka, D. “Stereoselective Pharmacological Effects of Lysergic Acid Amides Possessing Chirality in the Amide Substituent.” Behav. Brain Res., 1996, 73, 117-119

Monte, A. P.; Marona-Lewicka, D.; Parker, M. A.; Mayleben, M.; Mailman, R. B.; Wainscott, B.; Nelson, D. L.; Nichols, D. E. “Dihydrobenzofuran Analogues of Hallucinogens. 3. Models of 4-Substituted (2,5-Dimethoxyphenyl) alkylamine Derivatives with Rigidified Methoxy Groups.” J. Med. Chem., 1996, 39, 2953-2961.

Monte, A. P.; Marona-Lewicka, D.; Cozzi, N. V.; Nelson, D. L.; Nichols, D. E. “Conformationally Restricted Tetrahydro-1-Benzoxepin Analogs of Hallucinogenic Phenethylamines.” Med. Chem Res., 1995, 5, 651-663.

Monte, A. P.; Marona-Lewicka, D.; Kanthasamy, A.; Sanders-Bush, E.; Nichols, D. E. “Stereoselective LSD-like Activity in a Series of d-Lysergic Acid Amides of (R)- and (S)-2-Aminoalkanes.” J. Med. Chem., 1995, 38, 958-966.

Monte, A. P.; Marona-Lewicka, D.; Cozzi, N. V.; Nichols, D. E. “Synthesis and Pharmacological Evaluation of Benzofuran, Indan, and Tetralin Analogues of 3,4-Methylenedioxyamphetamine (MDA).” J. Med. Chem., 1993 36, 3700-3706.

Education

Ph.D., Medicinal Chemistry & Molecular Pharmacology, Purdue University, West Lafayette, IN, 1995

B.S., Chemistry & Biochemistry, University of West Florida, Pensacola, FL, 1990