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Jennifer Klein

Pronouns: She/Her/Hers
Adjunct Professor
Biology
University of Wisconsin-La Crosse

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Jennifer Klein Pronouns: She/Her/Hers

Adjunct Professor

Biology

Specialty area(s)

Medicine · Molecular Biophysics · Cell Biology · Molecular Biology · Biochemistry · Mathematical Biology

 

Brief biography

On a summer afternoon, I wade down a Driftless stream, gripped by tiny muddy fingers, collecting insects with elementary school learners before returning to a barn shared by horses and a row of microscopes. In my research laboratory, students gather around fluorescent images of skeletal muscle as we explore how molecular mechanisms contribute to muscle aging and whether those processes can be altered. On a molecular ecology sailing expedition, I help a student navigate the anxiety of losing sight of land and discover confidence through shared adventure. During the COVID-19 pandemic, I pause a Zoom lecture with 120 General Biology students—many isolated in their dorms and some actively infected—to make space for their symptoms, questions, and fears.

These moments reflect what has sustained me through more than 15 years as a biomedical researcher and professor: scientific discovery, mentorship, teaching, and the opportunity to connect science with human experience. My research has evolved from molecular mechanisms of aging and redox regulation in skeletal muscle toward translational studies of exercise, extracellular vesicles, muscle regeneration, and neuroprotection.

In 2026, I completed my medical training at the University of Wisconsin School of Medicine and Public Health through the Wisconsin Academy for Rural Medicine (WARM), bringing my background in biomedical research and education into clinical medicine. I remain committed to integrating scientific discovery, patient care, mentorship, and rural health.

I have included additional descriptions of my teaching and research projects in the hyperlinks below.

Current courses at UWL

Bio 105 General Biology

Bio 315 Cell Biology

Bio 435/535 Molecular Biology

BIO 449/549 Advanced Microscopy and Biological Imaging

Bio 460/560 Modern Genomics

Bio 460/560 Biophysics

Bio 460/560 Rural Health

Bio 491 Biology Capstone

Link to all Courses

Education

University of Wisconsin School of Medicine and Public Health (2022-2026)

National Institutes of Health NRSA Postdoctoral Training in the Biology of Aging (2010)

      University of Minnesota, Minneapolis, MN

Doctor of Philosophy in Biochemistry, Molecular Biology, and Biophysics (2008)

       University of Minnesota, Minneapolis, MN

       Dissertation Title: Myosin Structural Dynamics

Bachelor of Arts in Chemistry (2002)

       College of Saint Benedict, Saint Joseph, Minnesota

Career

Teaching history

After more than 15 years teaching at UWL, my core understanding of teaching and learning has remained remarkably consistent, even as its expression has expanded into places I once could not have imagined. My own liberal arts education strongly shaped how I approach science education, particularly how I motivate students. There are many reasons students choose to pursue science, but one of the most compelling is the pursuit of science in service to others.

Science can be timely, relevant, and captivating, as we have seen so clearly with COVID-19, yet we rarely teach science through this lens. I build and continually revise courses around authentic problems that I hope will fascinate students and draw them into a sustained drive toward understanding and success. Coupled with evidence-based approaches to science education—including learning communities, active learning, problem-solving, and guided inquiry—I have witnessed students achieve outcomes I once thought impossible for 20-year-olds.

I have come to see my role as an instructor as creating curiosity-provoking worlds for students to enter. As their guide, I describe the scenery, the dangers, and the riddles. I provide the right tools at the right time, demonstrate how to use them effectively, and then step back, giving students the intellectual space to plan, pursue, fail, and pursue again. In that space, students develop not only knowledge and scientific skills, but also the self-confidence and self-efficacy to become independent learners.

My transition into medical education has reinforced this philosophy. Whether teaching undergraduates, mentoring research students, or learning alongside medical trainees, I continue to believe that the most meaningful teaching is not about delivering answers. It is about creating the conditions in which learners become curious enough—and confident enough—to find them.

Professional history

University of Wisconsin-La Crosse (2012-Present)

St. Olaf College, Minnesota (2010-2012, Visiting Professor)

University of St. Thomas, Minnesota (2008-2010, Visiting Professor)

Minnesota Supercomputing Institute Fellow (2002)

Kudos

published

Jennifer Klein and Alder Yu, both Biology; Nabamita Dutta, Economics; Alysa Remsburg, Environmental Studies; Tesia Marshik, Psychology; and Adam Driscoll, Sociology & Criminal Justice; co-authored the article "New frontiers in student evaluations of teaching: university efforts to design and test a new instrument for student feedback" in Assessment & Evaluation in Higher Education published on April 5 by Taylor and Francis Online. This article summarizes the efforts put forth by the Ad-Hoc SEI committee with exploring the problematic use of SEIs on campus, selecting and modifying an alternative tool (the soon to be adopted LENS system), and conducting some early findings regarding its efficacy.

Submitted on: April 11, 2023

published

Scott Cooper, Jennifer Klein, Todd Osmundson, Anton Sanderfoot, Jaclyn Wisinski and Alder Yu, all Biology, co-authored the article "Instructional Innovations in College-Level Molecular Bioscience Labs during the Pandemic-Induced Shift to Online Learning" in Education Sciences published on Wednesday, March 23 by MDPI. Educ. Sci. 2022, 12(4), 230; https://doi.org/10.3390/educsci12040230

Submitted on: Mar. 23, 2022

published

Daniel Walgenbach, Cade Armstrong, College of Science & Health and Jacob Kailing, College of Science & Health, all Biochemistry (ASBMB Cert) BS; Alex Steil, Biology (Cell and Molecular Concentration); and Jennifer Klein, Biology, Biology; co-authored the article "The calmodulin redox sensor controls myogenesis" in PLOS ONE published on Sept. 17 by Public Library of Science (PLOS). Muscle aging is accompanied by blunted muscle regeneration in response to injury and disuse. Oxidative stress likely underlies this diminished response, but muscle redox sensors that act in regeneration have not yet been characterized. Students in Molecular Biology Lab (Bio 436) contributed to using the CRISPR-Cas9 gene editing system to introduce a single amino acid substitution M109Q that mimics oxidation of methionine to methionine sulfoxide in one or both alleles of the CALM1 gene, one of three genes encoding the muscle regulatory protein calmodulin, in C2C12 mouse myoblasts. When signaled to undergo myogenesis, mutated myoblasts failed to differentiate into myotubes. Students in Advanced Microscopy (Bio 449/549) found that although early myogenic regulatory factors were present, cells with the CALM1 M109Q mutation in one or both alleles were unable to withdraw from the cell cycle and failed to express late myogenic factors. We have shown that a single oxidative modification to a redox-sensitive muscle regulatory protein can halt myogenesis, suggesting a molecular target for mitigating the impact of oxidative stress in age-related muscle degeneration. Research was funded by the National Institutes of Health (National Institute of Aging). Over 100 UWL students contributed to this publication! Thank you to all of those students who braved the waters of course-embedded research and found success.

Submitted on: Sept. 19, 2020

interviewed

Jennifer Klein, Biology, was interviewed by IBM news on Thursday, June 18. Jennifer Klein describes her use of High Performance Computing to help design drugs to treat Covid 19.

Submitted on: June 18, 2020