Nicholas McGrath

Assistant Professor
Chemistry And Biochemistry
4009 Cowley Hall
608.785.8287
nmcgrath@uwlax.edu

Specialty area(s)

Synthetic Organic Chemistry, Chemical Biology

Current courses at UWL

CHM 300: Survey of Organic Chemistry
CHM 303: Organic Chemistry Theory
CHM 305: Organic Chemistry Laboratory

Teaching history

CHM 103: General Chemistry (Laboratory)
CHM 300: Survey of Organic Chemistry (Lecture & Laboratory)
CHM 303: Organic Chemistry Theory (Lecture)
CHM 305: Organic Chemistry (Laboratory)
CHM 405: Advanced Synthetic Organic Chemistry (Lecture & Laboratory)

Professional history

Assistant Professor of Chemistry, University of Wisconsin-La Crosse (2013-Present)

Research and publishing

Here is a link to my research webpage

15. Lucas, K. M.; Kleman, A. F.; Sadergaski, L. R.; Jolly, C. L.; Bollinger, B. S.; Mackesey, B. L.; McGrath, N. A.* Versatile, Mild, and Selective Reduction of Various Carbonyl Groups Using an Electron-Deficient Boron Catalyst, Org. Biomol. Chem. In Press. (Invited New Talent Issue).

14. Andersen, K. A.; Aronoff, M. R.; McGrath, N. A.; Raines, R. T. Diazo Groups Endure Metabolism and Enable Chemoselectivity in cellulo, J. Am. Chem. Soc. 2015, 137, 2412-2415.

13. McGrath, N. A.; Andersen, K. A.; Davis, A. K. F.; Raines, R. T. Diazo Compounds for the Bioreversible Esterification of Proteins, Chem. Sci. 2015, 6, 752-755.

12. Marshall, C. J.; Agarwal, N.; Kalia, J.; Grosskopf, V. A.; McGrath, N. A.; Abbott, N. L.; Raines, R. T.; Shusta, E. V. Facile Chemical Functionalization of Proteins Through Intein-Linked Yeast Display, Bioconjugate Chemistry 2013, 24, 1634-1644.

11. McGrath, N. A.; Raines, R. T. Diazo-Compounds as Highly Tunable Reactants in 1,3-Dipolar Cycloaddition Reactions With Cycloalkynes, Chem. Sci. 2012, 3, 3237-3240.

10. McGrath, N. A.; Brichacek, M. Trifluoroperacetic Acid, Encyclopedia of Reagents for Organic Synthesis, 2012, John Wiley & Sons Ltd.

9. Palte, M. J.; Davis, A. K. F.; McGrath, N. A.; Raines, R. T. Ribonucleoside 3’-Phosphates as Pro-moieties for an Orally Administered Drug, ChemMedChem 2012, 7, 1361-1364.

8. Ellis, G. A.; McGrath, N. A.; Palte, M. J.; Raines, R. T. Ribonuclease-Activated Cancer Prodrug, ACS Med. Chem. Lett. 2012, 3, 268-272. {Co-first author}

7. McGrath, N. A.; Raines, R. T. Chemoselectivity in Chemical Biology: Acyl Transfer Reactions with Sulfur and Selenium, Acc. Chem. Res. 2011, 44, 752-761.

6. McGrath, N. A.; Binner, J. R.; Markopoulos, G.; Brichacek, M.; Njardarson, J. T. An Efficient Oxidative Dearomatization-Radical Cyclization Approach to Symmetrically Substituted Bicyclic Guttiferone Natural Product, Chem. Comm. 2011, 47, 209-211.

5. Brichacek, M.; Batory, L. A.; McGrath, N. A.; Njardarson, J. T. The Strategic Marriage of Method and Motif, Tetrahedron 2010, 66, 4832-4840.

4. McGrath, N. A.; Brichacek, M.; Njardarson, J. T. A Graphical Journey of Innovative Organic Architectures That Have Improved Our Lives, J. Chem. Educ. 2010, 87, 1348-1349.

3. McGrath, N. A.; Bartlett, E. S.; Sittihan, S.; Njardarson, J. T. A Concise Ring Expansion Route to the Compact Core of Platensimycin, Angew. Chem. Int. Ed. 2009, 48, 8543-8546.

2. McGrath, N. A.; Lee, C. A.; Araki, H.; Brichacek, M.; Njardarson, J. T. An Efficient Substrate-controlled Route Towards Hypoestoxide, a Member of a Family of Diterpenoid Natural Products with an Inside-out [9.3.1] Bicyclic Core, Angew. Chem. Int. Ed. 2008, 47, 9450-9453.

1. Lazareva, M. I.; Nguyen, S. T.; Nguyen, M. C.; Emiru, H.; McGrath, N. A.; Caple, R.; Smit, W. A. μ-Alkyne Dicobalt Hexacarbonyl Complexes of Conjugated Enynes as Substrates in the Arylthio-mediated Stepwise AdE Reactions, Mendeleev. Commun. 2001, 6, 224-227.

Education

NIH Postdoctoral Fellow, University of Wisconsin-Madison (2010-2013) {R. Raines}
Ph.D. Organic Chemistry, Cornell University, Ithaca, NY (2010) {J. Njardarson}
M.S. Organic Chemistry, University of Minnesota-Duluth, Duluth, MN (2005) {R. Carlson}
B.S. Chemistry, University of Minnesota-Duluth, Duluth, MN (2003) {R. Caple)