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Sumei Liu

Professor
Biology University of Wisconsin-La Crosse

Sumei Liu

Professor

Biology

Specialty area(s)

Gastrointestinal Physiology; Enteric Nervous System

Current courses at UWL

BIO 312/313 Human Anatomy and Physiology I&II

BIO 458/558 Comparative Animal Physiology

BIO 491 Capstone

BIO 499 Independent Research

BIO 719 Advanced Human Physiology II

Education

Ph. D. Ohio State University, Columbus, OH, 2002
Major: Physiology and Cell Biology

M.S. Beijing Normal University, Beijing, China, 1993
Major: Physiology

B.S. Beijing Normal University, Beijing, China, 1990
Major: Biology

Career

Research and publishing

Research areas:
(1) Effects of stress on gastrointestinal function
(2) Effects of hibernation on gastrointestinal motility
(3) Using novel technology of micro vibration to strengthen skeletal muscle and bone

Publications:

  1. Liu S, Karo A, Agterberg S, Hua H, Bhargava A. Effects of stress-related peptides on chloride secretion in the mouse proximal colon. Neurogastroenterol Motil. 2021 Apr;33(4):e14021. doi: 10.1111/nmo.14021. PMID: 33118282.
  2. Liu S. Neurotrophic factors in enteric physiology and pathophysiology. Neurogastroenterol Motil. 2018. doi: 10.1111/nmo. 13446.
  3. Liu S, Hagiwara SI, Bhargava A. Early-life adversity, epigenetics, and visceral hypersensitivity. Neurogastroenterol Motil. 2017 Sep;29(9). doi: 10.1111/nmo.
  4. Liu S, Chang J, Long N*, Beckwith K*, Talhouarne G*, Brooks, JJ, Q M-H, Ren W, Wood JD, Cooper S, Bhargava A. Endogenous CRF in rat large intestine mediates motor and secretory responses to stress. Neurogastroenterol Motil 2016;28(2):281-291. (* undergraduate co-authors)
  5. Wang GD, Wang XY, Liu S, Xia Y, Zou F, Qu M, Needleman BJ, Mikami DJ, Wood JD. β-Nicotinamide adenine dinucleotide acts at prejunctional adenosine A1 receptors to suppress inhibitory musculomotor neurotransmission in guinea pig colon and human jejunum. Am J Physiol Gastrointest Liver Physiol 2015;308(11):G955–63.
  6. Wang GD, Wang XY, Liu S, Qu M, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Innervation of enteric mast cells by primary spinal afferents in guinea pig and human small intestine. Am J Physiol Gastrointest Liver Physiol 2014;307(7):G719-31.
  7. Wang GD, Wang XY, Zou F, Qu M, Liu S, Fei G, Xia Y, Needleman BJ, Mikami DJ, Wood JD. Mast cell expression of the serotonin 1A receptor in guinea pig and human intestine. Am J Physiol Gastrointest Liver Physiol 2013 304(10):G855-63.
  8. Fei G, Fang X, Wang GD, Liu S, Wang XY, Xia Y, Wood JD. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum. Br J Pharmacol 2013;168(4):880-90.
  9. Ji T, Liu S, Zheng LF, Wang Q, Dou ZF, Zhang Y, Zhu JX. Cellular distribution of NKCC2 in the gastric mucosa and its response to short-term osmotic shock. Cell and Tissue Research 2012;348(1):155-65.
  10. Xu JD#, Liu S#, Wang W, Li LS, Li XF, Li Y, Guo H, Hou XL, Zhang Y, Zhu J-X. Emodin induces chloride secretion in rat distal colon through activation of mast cells and enteric neurons. Br J Pharmacol 2012;165(1):197-207. (#Both authors contributed equally to this work.)
  11. Wood JD, Liu S, Drossman DA, Ringel Y, Whitehead, WE. Anti-Enteric Neuronal Antibodies and the Irritable Bowel Syndrome. J Neurogastroenterol Motil 2012;18(1):78-85.
  12. Sun X, Wang X, Wang GD, Xia Y, Liu S, Qu M, Needleman BJ, Mikami DJ, Scott Melvin W, Bohn LM, Ueno R, Wood JD. Lubiprostone Reverses the Inhibitory Action of Morphine on Mucosal Secretion in Human Small Intestine. Dig Dis Sci 2011;56(2):330-8.
  13. Zhang XH, Ji T, Guo H, Liu SM, Li Y, Zheng LF, Zhang Y, Zhang XF, Duan ZP, Zhu JX. Expression and activation of β-adrenoceptors in the colorectal mucosa of rat and human. Neurogastroenterol Motil 2010;22(11):e325-34.
  14. Fei G, Raehal K, Liu S, Qu M, Sun X, Wang GD, Wang XY, Xia Y, Schmid CL, Bohn LM, Wood JD. Lubiprostone (SPI-0211) reverses the inhibitory action of morphine on intestinal secretion in guinea pig and mouse. J Pharmacol Exp Ther 2010; 334(1):333-40.
  15. Yang N#, Liu SM#, Zheng LF, Ji T, Li Y, Mi XL, Xue H, Ren W, Xu JD, Zhang XH, Li LS, Zhang Y, Zhu JX. Activation of submucosal 5-HT(3) receptors elicits a somatostatin-dependent inhibition of ion secretion in rat colon. Br J Pharmacol. 2010;159(8):1623-35. (#Both authors contributed equally to this work.)
  16. Liu S, Ren W, Qu M-H, Bishop GA, Wang GD, Wang XY, Xia Y, Wood JD. Differential Actions of Urocortins on Neurons of the Myenteric Division of the Enteric Nervous System in Guinea Pig Distal Colon. British Journal of Pharmacology 2010;159(1):222-36.
  17. Baldassano S, Liu S, Qu MH, Mule F, Wood JD. Glucagon-Like Peptide-2 Modulates Neurally-Evoked Mucosal Chloride Secretion In Guinea Pig Small Intestine In Vitro. Am J Physiol Gastrointest Liver Physiol 2009; 297(4):G800-5.
  18. Xue H#, Liu S#, Ji T, Ren W, Zhang XH, Zheng LF, Wood JD, Zhu JX. Expression of NKCC2 in the rat gastrointestinal tract. Neurogastroenterol Motil 2009;21(10):1068-e89. (#Both authors contributed equally to this work.)
  19. Fei G, Wang YZ, Liu S, Hu HZ, Wang GD, Qu MH, Wang XY, Xia Y, Sun X, Bohn LM, Cooke HJ, Wood JD. Stimulation of Mucosal Secretion by Lubiprostone (SPI-0211) in Guinea Pig Small Intestine and Colon. Am J Physiol Gastrointest Liver Physiol 2009;296(4):G823-32.
  20. Liu S, Ren W, Qu M-H, Hu H-Z, Gao N, Wang G-D, Wang X-Y, Fei G, Zuo F, Xia Y, Wood JD. Differential Expression of Canonical (Classical) Transient Receptor Potential Channels in Guinea Pig Enteric Nervous System. J Comp Neurol 2008;511(6):847-62.
  21. Kokkotou E, Moss AC, Torres D, Karagiannides I, Cheifetz A, Liu S, O’Brien M, Maratos-Flier E, Pothoulakis C. Melanin-concentrating hormone (MCH) as a mediator of intestinal inflammation. Proc Natl Acad Sci USA 2008;105(30):10613-8.
  22. Fang X, Liu S, Wang XY, Gao N, Hu HZ, Wang GD, Cook CH, Needleman BJ, Mikami DJ, Xia V, Fei GJ, Hicks GA, Wood JD. Neurogastroenterology of tegaserod (HTF 919) in the submucosal division of the guinea-pig and human enteric nervous system. Neurogastroenterol Motil 2008;20(1):80-93.
  23. Wang GD, Wang XY, Hu HZ, Liu S, Gao N, Fang X, Xia Y, Wood JD. Inhibitory Neuromuscular Transmission Mediated by the P2Y1 Purinergic Receptor in Guinea-Pig Small Intestine. Am J Physiol Gastrointest Liver Physiol 2007; 292(6):G1483-9.
  24. Gao N, Hu HZ, Liu S, Gao C, Xia Y, Wood JD. Stimulation of Adenosine A1 and A2A Receptors by Adenosine 5'-monophosphate (AMP) in the Submucosal Plexus of Guinea-pig Small Intestine. Am J Physiol Gastrointest Liver Physiol 2007; 292(2):G492-500.
  25. Wang GD, Wang XY, Hu HZ, Fang XC, Liu S, Gao N, Xia Y. Platelet-activating factor in the enteric nervous system of the guinea pig small intestine. Am J Physiol Gastrointest Liver Physiol 2006;291(5):G928-37.
  26. Fang X, Hu HZ, Gao N, Liu S, Wang GD, Wang XY, Xia Y, Wood JD. Neurogenic secretion mediated by the purinergic P2Y1 receptor in guinea-pig small intestine. Eur J Pharmacol 2006;536(1-2):113-22.
  27. Gao N, Hu HZ, Zhu MX, Fang X, Liu S, Gao C, Wood JD. The P2Y1 purinergic receptor expressed by enteric neurons in guinea-pig intestine. Neurogastroenterol Motil 2006;18(4):316-23.
  28. Liu S, Gao N, Hu H-Z, Wang X, Wang GD, Fang X, Gao X, Xia Y, Wood JD. Distribution and chemical coding of corticotropin releasing factor-immunoreactive neurons in the guinea-pig enteric nervous system. J Comp Neurol 2006; 494(1):63-74.
  29. Wang GD, Wang XY, Hu HZ, Fang XC, Liu S, Gao N, Xia Y, Wood JD. Angiotensin receptors and actions in guinea pig enteric nervous system. Am J Physiol Gastrointest Liver Physiol 2005; 289(3):G614-26.
  30. Liu S, Gao X, Gao N, Wang X, Hu H-Z, Fang X, Wang G, Xia Y, Wood JD. Expression of the type 1 corticotropin-releasing factor receptor (CRF1) in the guinea-pig enteric nervous system. J Comp Neurol 2005; 481(3):284-98.
  31. Wood JD, Liu S. Galanin receptors and actions. Drugs of the Future 2004; 29:149-161 (Review).
  32. Hu HZ, Gao N, Liu S, Ren J, Wang X, Xia Y, Wood JD. Action of bradykinin in the submucosal plexus of guinea-pig small intestine. J Pharmacol Exp Ther 2004; 309(1):320-327.
  33. Hu HZ, Gao N, Liu S, Ren J, Xia Y, Wood JD. Metabotropic signal transduction for bradykinin in submucosal neurons of guinea-pig small intestine. J Pharmacol Exp Ther 2004; 309(1):310-319.
  34. Liu S, Hu HZ, Gao C, Gao N, Xia Y, Wood JD. Actions of galanin on neurotransmission in the submucosal plexus of guinea pig small intestine. Eur J Pharmacol 2003; 471(1):49-58.
  35. Hu HZ, Liu S, Gao N, Xia Y, Mostafa R, Ren J, Zafirov DH, Wood JD. Actions of bradykinin on electrical and synaptic behavior of neurons in the myenteric plexus of guinea-pig small intestine. Br J Pharmacol 2003; 138(7):1221-32.
  36. Hu HZ, Gao N, Zhu MX, Liu S, Ren J, Gao C, Xia Y, Wood JD. Slow excitatory synaptic transmission mediated by P2Y1 receptors in the guinea-pig enteric nervous system. J Physiol 2003; 550(Pt 2):493-504.
  37. Liu S, Hu HZ, Gao C, Gao N, Wang G, Wang X, Gao X, Xia Y, Wood JD. Actions of cysteinyl leukotrienes in the enteric nervous system of guinea-pig stomach and small intestine. Eur J Pharmacol 2003; 459(1):27-39.
  38. Liu S, Hu HZ, Gao N, Wang GD, Wang X, Peck OC, Kim GY, Xia Y, Wood JD. Neuroimmune interactions in guinea-pig stomach and small intestine: a signaling role for histamine, prostaglandins and leukotrienes. Am J Physiol Gastrointest Liver Physiol 2003; 284(1):G154-G164.
  39. Gao C, Liu S, Hu HZ, Gao N, Kim GY, Xia Y, Wood JD. Serine proteases excite myenteric neurons through protease-activated receptors in guinea-pig small intestine. Gastroenterology 2002; 123:1554-1564.
  40. Lin Z, Gao N, Hu HZ, Liu S, Gao C, Kim GY, Ren J, Xia Y, Peck OC, Wood JD. Immunoreactivity of Hu proteins facilitates identification of myenteric neurons in guinea-pig small intestine. Neurogastroenterol Motil 2002; 14(2):197-204.
  41. Hu HZ, Gao N, Lin Z, Gao C, Liu S, Ren J, Xia Y, Wood JD. Chemical coding and electrophysiology of enteric neurons expressing neurofilament 145 in guinea pig gastrointestinal tract. J Comp Neurol 2002; 442(3):189-203.
  42. Liu S, Hu HZ, Ren J, Gao C, Gao N, Lin Z, Xia Y, Wood JD. Pre- and postsynaptic inhibition by nociceptin in guinea pig small intestinal myenteric plexus in vitro. Am J Physiol Gastrointest Liver Physiol 2001; 281(1):G237-G246.
  43. Hu HZ, Gao N, Lin Z, Gao C, Liu S, Ren J, Xia Y, Wood JD. P2X(7) receptors in the enteric nervous system of guinea-pig small intestine. J Comp Neurol 2001; 440(3):299-310.
  44. Xia Y, Hu HZ, Liu S, Pothoulakis C, Wood JD. Clostridium Difficule Toxin-A excites enteric neurons and suppresses sympathetic neurotransmission in the guinea pig. Gut 2000; 46(4):481-486.
  45. Liu S, Xia Y, Hu HZ, Ren J, Gao C, Wood JD. Histamine H3 receptor-mediated suppression of inhibitory synaptic transmission in the guinea-pig submucous plexus. Eur J Pharmacol 2000; 397(1):49-54.
  46. Ren J, Hu HZ, Liu S, Xia Y, Wood JD. Glutamate receptors in the enteric nervous system: ionotropic or metabotropic? Neurogastroenterol Motil 2000; 12(3):257-264.
  47. Ren J, Hu HZ, Liu S, Xia Y, Wood JD. Glutamate modulates synaptic transmission in the submucous plexus of guinea pig small intestine. Neuroreport 1999; 10(14):3045-3048.
  48. Hu HZ, Ren J, Liu S, Gao C, Xia Y, Wood JD. Functional expression of group I metabotropic glutamate receptors in submucous plexus of guinea-pig ileum. Br J Pharmacol 1999; 128(8):1631-1635.
  49. Xia Y, Hu HZ, Liu S, Ren J, Zafirov DH, Wood JD. IL-1b and IL-6 excite neurons and suppress nicotinic and noradrenergic neurotransmission in guinea pig enteric nervous system. J Clin Invest 1999; 103(9):1309-1316.

Funding sources:
NIH NIDDK AREA DK097460-01A1
UWL Foundation

 

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