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PURPOSE: 

The intent of this policy is to define the requirements and process for the review and approval of protocols that propose the use of hazardous materials in live animals.

REFERENCE: 

Guide for the Care and Use of Laboratory Animals 8th edition, page 20. 

DEFINITIONS:

Hazardous Agent – Biological agents (e.g., infectious agents, toxins, recombinant DNA), chemical agents (e.g., carcinogens, irritants, mutagens), and physical hazards (e.g., radiation, lasers, noise).

POLICY: 

The use of hazardous agents in live teaching or research animals requires the approval of Appendix F by an Institutional Biosafety Committee (IBC) to secure approval of the animal care and use protocol. The Principal Investigator (PI) is the primary person responsible for ensuring that each person handling hazardous agents and the animals is trained prior to their use.

PROCEDURE FOR UW-LA CROSSE PI’s:

• The PI completes the Animal Care and Use Protocol including Appendix F and submits the documents to the IACUC office (IACUC@uwlax.edu) for review by the committee.
• The PI submits a copy of the Animal Care and Use Protocol including Appendix F to the IBC Chair along with the IBC-1 form for review.
• When Appendix F and the IBC-1 forms are approved by the IBC, the PI forwards the approval letter to the IACUC office to include with the Animal Care and Use Protocol. 
• The PI may not begin any animal experiments until they receive a protocol approval letter from the IACUC office.

PROCEDURE FOR NON UW-LA CROSSE PRINCIPAL INVESTIGATORS:

• The PI completes the Animal Care and Use Protocol including Appendix F and submits the documents to the IACUC office (IACUC@uwlax.edu) for review by the committee.
• The PI submits a copy of the Animal Care and Use Protocol including Appendix F to their institutions safety committee along with any other required forms for review.
• When Appendix F has been approved and signed by their Institutions safety committee, the PI forwards the approval letter to the IACUC office to include with the Animal Care and Use Protocol. 
• The PI may not begin any animal experiments until they receive a protocol approval letter from the IACUC office.

Prepared by: Amy Cooper

Adoption Date: 4/8/14
Amended: 2/5/16
Reference minutes: 4/8/14, 1/18/16